{"product_id":"proteintech-80137-1-rr","title":"Proteintech, 80137-1-RR, MAP2K3 Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe MAP2K3 (80137-1-RR) by Proteintech is a Recombinant antibody targeting MAP2K3 in WB, IF\/ICC, ELISA applications with reactivity to human, mouse, rat, zebrafish samples\n80137-1-RR targets MAP2K3 in WB, IF\/ICC, ELISA applications and shows reactivity with human, mouse, rat, zebrafish samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: Jurkat cells, A431 cells,  C6 cells,  HepG2 cells,  HT-1080 cells,  zebrafish tissue,  C2C12 cells,  NIH\/3T3 cells,  HeLa cells,  HEK-293 cells\nPositive IF\/ICC detected in: HeLa cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:2000-1:10000\nImmunofluorescence (IF)\/ICC: IF\/ICC : 1:200-1:800\n\u003cb\u003eBackground Information\u003c\/b\u003e\nMAP2K3, also named MKK3, is a member of dual specificity kinase group and serves as a specific activator of p38 MAPK with MKK6. MKK3 can be phosphorylated by cytokines and environmental stress at sites Ser189 and Thr193 by MKKK proteins (MEKK 1-4).  MKK3 plays a key role in cell differentiation, motility, division and death. It has been reported that MKK3 targeting may represent an effective and potentially safe therapeutic strategy to selectively kill cancer cells in colorectal cancer patients. (PMID: 31695024, 30770795, 26805700, 8622669)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse, rat, zebrafish\nCited Reactivity: mouse\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: mitogen-activated protein kinase kinase 3\nCalculated Molecular Weight: 347 aa, 39 kDa\nObserved Molecular Weight: 39 kDa\nGenBank Accession Number: BC032478\nGene Symbol: MAP2K3\nGene ID (NCBI): 5606\nRRID: AB_2918868\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: P46734\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888349597865,"sku":"80137-1-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/proteintech-80137-1-rr","provider":"Iright","version":"1.0","type":"link"}