{"product_id":"proteintech-81180-2-rr","title":"Proteintech, 81180-2-RR, Phospho-Paxillin (Tyr118) Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-Paxillin (Tyr118) (81180-2-RR) by Proteintech is a Recombinant antibody targeting Phospho-Paxillin (Tyr118) in WB, IF\/ICC, ELISA applications with reactivity to human samples\n81180-2-RR targets Phospho-Paxillin (Tyr118) in WB, IF\/ICC, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: pervanadate treated HeLa cells\nPositive IF\/ICC detected in: A549 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:2000-1:10000\nImmunofluorescence (IF)\/ICC: IF\/ICC : 1:250-1:1000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nPaxillin (p68-kD) is one of the integrin assembly proteins and can interact directly with several integrin assembly proteins, including vinculin, talin, β1 integrin, focal adhesion kinase (FAK), c-Src and Csk. Integrin-mediated tyrosine phosphorylation also enables paxillin to interact with various signaling molecules: tyrosine residues (Y) 31 and 118 being especially predominant targets of phosphorylation by kinases and creating binding sites for the SH2 domain of adaptor protein Crk. Thus, paxillin plays apivotal role in cell adhesion, migration and further oncogenic transformation. (PMID: 11774284)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: paxillin\nCalculated Molecular Weight: 591 aa, 65 kDa\nObserved Molecular Weight: 68 kDa\nGenBank Accession Number: BC136787\nGene Symbol: Paxillin\nGene ID (NCBI): 5829\nRRID: AB_3670493\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purfication\nUNIPROT ID: P49023\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888656208041,"sku":"81180-2-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/proteintech-81180-2-rr","provider":"Iright","version":"1.0","type":"link"}