{"product_id":"proteintech-85707-1-rr","title":"Proteintech, 85707-1-RR, KIF14 Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe KIF14 (85707-1-RR) by Proteintech is a Recombinant antibody targeting KIF14 in WB, ELISA applications with reactivity to human samples\n85707-1-RR targets KIF14 in WB, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: HeLa cells, HEK-293T cells,  T-47D cells,  HL-60 cells,  Jurkat cells,  Raji cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:2000-1:10000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nKIF14 (Kinesin Family Member 14) is a microtubule-based motor protein belonging to the kinesin-3 family. It plays essential roles during cell division and has been implicated in various biological processes, including vesicle transport, chromosome segregation, mitotic spindle formation, and cytokinesis. KIF14 is highly conserved across species and is characterized by a catalytic motor domain that binds to microtubules and ATP, enabling it to convert chemical energy into mechanical work. KIF14 interacts with the Skp1\/Cul1\/F-box (SCF) complex, particularly Skp2 and Cks1, to regulate the ubiquitination and degradation of p27Kip1. Knockdown of KIF14 results in the accumulation of p27Kip1, leading to cell cycle arrest and apoptosis.(PMID: 34131133, PMID: 24854087)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: CatNo: Ag23219 Product name: Recombinant human KIF14 protein Source: e coli. -derived, PET30a Tag: 6*His Domain: 1299-1648 aa of BC113742 Sequence: SDRAIQSLTIQTACAFEQLVVLMKHWLSDLLPCTNIARLEDELRQEVKKLGGYLQLFLQGCCLDISSMIKEAQKNAIQIVQQAVKYVGQLAVLKGSKLHFLENGNNKAASVQEEFMDAVCDGVGLGMKILLDSGLEKAKELQHELFRQCTKNEVTKEMKTNAMGLIRSLENIFAESKIKSFRRQVQEENFEYQDFKRMVNRAPEFLKLKHCLEKAIEIIISALKGCHSDINLLQTCVESIRNLASDFYSDFSVPSTSVGSYESRVTHIVHQELESLAKSLLFCFESEESPDLLKPWETYNQNTKEEHQQSKSSGIDGSKNKGVPKRVYELHGSSAAVSSEECTPSRIQWV Predict reactive species\nFull Name: kinesin family member 14\nObserved Molecular Weight: 186 kDa\nGenBank Accession Number: BC113742\nGene Symbol: KIF14\nGene ID (NCBI): 9928\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: Q15058\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888774303913,"sku":"85707-1-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/proteintech-85707-1-rr","provider":"Iright","version":"1.0","type":"link"}