{"product_id":"proteintech-85730-1-rr","title":"Proteintech, 85730-1-RR, NCDN Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe NCDN (85730-1-RR) by Proteintech is a Recombinant antibody targeting NCDN in WB, IHC, IF-P, ELISA applications with reactivity to human, mouse, rat samples\n85730-1-RR targets NCDN in WB, IHC, IF-P, ELISA applications and shows reactivity with human, mouse, rat samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: mouse brain tissue, rat brain tissue,  fetal human brain tissue\nPositive IHC detected in: mouse brain tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0\nPositive IF-P detected in: mouse brain tissue\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:5000-1:50000\nImmunohistochemistry (IHC): IHC : 1:500-1:2000\nImmunofluorescence (IF)-P: IF-P : 1:200-1:800\n\u003cb\u003eBackground Information\u003c\/b\u003e\nNCDN protein (Neurochondrin) is a highly conserved 79 kDa adaptor protein, which was first discovered in 1997 and mainly expressed in the nervous system. NCDN protein plays an important role in neuronal differentiation, formation and maintenance of dendritic spines. It is involved in the development of synapses, neuronal differentiation and signal transduction, and maintains cell polarity by regulating dendritic morphogenesis and neural signal pathway. Recent studies have found that NCDN protein is expressed not only in neurons, but also in myeloid cells (such as neutrophils), and plays a role as a negative regulator of innate immunity. Mice lacking NCDN in myeloid cells are more immune to bacterial infection because of the increased reactivity of neutrophils (PMID: 37503670). The molecular weight of NCDN is 78 kDa.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse, rat\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: CatNo: Ag3859 Product name: Recombinant human NCDN protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 426-729 aa of BC024592 Sequence: KTLYEEAEEANDLSQQVANLAISPTTPGPTWPGDALRLLLPGWCHLTVEDGPREILIKEGAPSLLCKYFLQQWELTSPGHDTSVLPDSVEIGLQTCCHIFLNLVVTAPGLIKRDACFTSLMNTLMTSLPALVQQQGRLLLAANVATLGLLMARLLSTSPALQGTPASRGFFAAAILFLSQSHVARATPGSDQAVLALSPEYEGIWADLQELWFLGMQAFTGCVPLLPWLAPAALRSRWPQELLQLLGSVSPNSVKPEMVAAYQGVLVELARANRLCREAMRLQAGEETASHYRMAALEQCLSEP Predict reactive species\nFull Name: neurochondrin\nCalculated Molecular Weight: 729 aa, 79 kDa\nObserved Molecular Weight: 75-79 kDa\nGenBank Accession Number: BC024592\nGene Symbol: Neurochondrin\nGene ID (NCBI): 23154\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: Q9UBB6\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888788623529,"sku":"85730-1-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/proteintech-85730-1-rr","provider":"Iright","version":"1.0","type":"link"}