{"product_id":"proteintech-85740-1-rr","title":"Proteintech, 85740-1-RR, SCN11A Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe SCN11A (85740-1-RR) by Proteintech is a Recombinant antibody targeting SCN11A in WB, IHC, ELISA applications with reactivity to human, mouse, rat samples\n85740-1-RR targets SCN11A in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: rat brain tissue, rat cerebellum tissue\nPositive IHC detected in: rat cerebellum tissue, mouse brain tissue,  rat brain tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:500-1:2000\nImmunohistochemistry (IHC): IHC : 1:1500-1:6000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nSodium channel protein type 11 subunit alpha (SCN11A, also known as Nav1.9) is crucial for generating action potentials and regulating neuronal excitability, particularly in nociceptive neurons of the dorsal root ganglia (DRG) and trigeminal ganglia (PMID: 33752606). Nav1.9 channels are involved in the formation of pain-sensing and have been implicated in peripheral inflammatory pain hypersensitivity. Additionally, SCN11A-mediated channels play a role in regulating colonic motility and neurotransmitter release in the enteric nervous system (PMID: 35711274).\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse, rat\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: sodium channel, voltage-gated, type XI, alpha subunit\nCalculated Molecular Weight: 205 kDa\nObserved Molecular Weight: 205 kDa\nGenBank Accession Number: NM_001349253\nGene Symbol: SCN11A\nGene ID (NCBI): 11280\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: Q9UI33\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888442593449,"sku":"85740-1-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/proteintech-85740-1-rr","provider":"Iright","version":"1.0","type":"link"}