{"product_id":"proteintech-86974-2-rr","title":"Proteintech, 86974-2-RR, HP1BP3 Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe HP1BP3 (86974-2-RR) by Proteintech is a Recombinant antibody targeting HP1BP3 in WB, ELISA applications with reactivity to human samples\n86974-2-RR targets HP1BP3 in WB, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: HeLa cells, HepG2 cells,  MCF-7 cells,  EC109 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:500-1:2000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nHP1BP3 (heterochromatin protein 1-binding protein 3) is an evolutionarily conserved nuclear protein that functions as a non-canonical linker histone. It is broadly expressed in most vertebrate tissues and is structurally related to the histone H1 family, containing three globular domains and a highly basic C-terminal tail reminiscent of H1 proteins . Unique to HP1BP3 are an acidic N-terminal stretch and a consensus HP1-binding motif (PxVxL), through which it associates with heterochromatin protein 1 (HP1α\/β) and is enriched at perinucleolar heterochromatin regions marked by H3K9me3. Functionally, HP1BP3 acts as a modulator of gene expression and genome stability. Alternative splicing was reported to produce 4 different isoforms of HP1BP3, the calculated MW corresponding to 61, 57, 44, 15 kDa.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: CatNo: Ag18709 Product name: Recombinant human HP1BP3 protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 1-302 aa of BC045660 Sequence: MASSPRPKMDAILTEAIKACFQKSGASVVAIRKYIIHKYPSLELERRGYLLKQALKRELNRGVIKQVKGKGASGSFVVVQKSRKTPQKSRNRKNRSSAVDPEPQVKLEDVLPLAFTRLCEPKEASYSLIRKYVSQYYPKLRVDIRPQLLKNALQRAVERGQLEQITGKGASGTFQLKKSGEKPLLGGSLMEYAILSAIAAMNEPKTCSTTALKKYVLENHPGTNSNYQMHLLKKTLQKCEKNGWMEQISGKGFSGTFQLCFPYYPSPGVLFPKKEPDDSRDEDEDEDESSEEDSEDEEPPPK Predict reactive species\nFull Name: heterochromatin protein 1, binding protein 3\nCalculated Molecular Weight: 553 aa, 61 kDa\nObserved Molecular Weight: 75 kDa\nGenBank Accession Number: BC045660\nGene Symbol: HP1BP3\nGene ID (NCBI): 50809\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: Q5SSJ5\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888763392169,"sku":"86974-2-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/proteintech-86974-2-rr","provider":"Iright","version":"1.0","type":"link"}