{"product_id":"proteintech-87066-3-rr","title":"Proteintech, 87066-3-RR, MRE11 Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe MRE11 (87066-3-RR) by Proteintech is a Recombinant antibody targeting MRE11 in WB, IP, ELISA applications with reactivity to human, mouse samples\n87066-3-RR targets MRE11 in WB, IP, ELISA applications and shows reactivity with human, mouse samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: HeLa cells, HepG2 cells,  HEK-293 cells,  A431 cells,  Jurkat cells,  K-562 cells,  RAW 264.7 cells\nPositive IP detected in: HeLa cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:5000-1:50000\nImmunoprecipitation (IP): IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate\n\u003cb\u003eBackground Information\u003c\/b\u003e\nMre11 (meiotic recombination 11), also named as Mre11A, is a component of the MRN( MRE11\/RAD50\/NBS1) complex which is a versatile complex, playing a key role in the sensing, processing, and repair of DSBs. MRE11 possesses both endonuclease and 3'-5' exonuclease activity. It contains two DNA-binding domains (DBDs), enabling it to bind both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). After DSBs, MRE11 is loaded onto DSBs sites and cleaves DNA by cooperating with CtIP (CtBP [C terminal binding protein] interacting protein) to initiate end resection. It's reported that MRE11 is over-expressed in breast cancers. (PMID:38128537; 22914783)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: CatNo: Ag1105 Product name: Recombinant human MRE11A protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 1-206 aa of BC005241 Sequence: MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGDLFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYGLGSIPDERLYRMFVNKKVTMLRPKED Predict reactive species\nFull Name: MRE11 meiotic recombination 11 homolog A (S. cerevisiae)\nCalculated Molecular Weight: 81 kDa\nObserved Molecular Weight: 81 kDa\nGenBank Accession Number: BC005241\nGene Symbol: MRE11A\nGene ID (NCBI): 4361\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: P49959\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888785313961,"sku":"87066-3-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/proteintech-87066-3-rr","provider":"Iright","version":"1.0","type":"link"}