{"product_id":"proteintech-87153-1-rr","title":"Proteintech, 87153-1-RR, Phospho-CD19 (Tyr531) Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-CD19 (Tyr531) (87153-1-RR) by Proteintech is a Recombinant antibody targeting Phospho-CD19 (Tyr531) in WB, ELISA applications with reactivity to human samples\n87153-1-RR targets Phospho-CD19 (Tyr531) in WB, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: Ramos cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:5000-1:50000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nCD19 is a 95 kDa type I transmembrane glycoprotein belonging to the immunoglobulin superfamily. Phospho-CD19 (Tyr531) is a phosphorylated form of CD19, which is a protein involved in B cell receptor (BCR) signaling and plays a crucial role in B cell development and function. Phosphorylation of CD19 at Tyr531 is known to recruit PI3K activity leading to Akt activation and attendant S473 phosphorylation. This activation of BCR induces multiple oncogenic signals and treatment with ibrutinib prevents preferentially the activation of BTK in both patients with ABC-like and GCB-like molecular features. (PMID: 20038598)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: CD19 molecule\nCalculated Molecular Weight: 556 aa, 61 kDa\nObserved Molecular Weight: 95 kDa\nGenBank Accession Number: NM_001770\nGene Symbol: CD19\nGene ID (NCBI): 930\nENSEMBL Gene ID: ENSG00000177455\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: P15391\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888800092329,"sku":"87153-1-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/proteintech-87153-1-rr","provider":"Iright","version":"1.0","type":"link"}