{"product_id":"proteintech-87317-1-rr","title":"Proteintech, 87317-1-RR, DHX30 Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe DHX30 (87317-1-RR) by Proteintech is a Recombinant antibody targeting DHX30 in WB, IF\/ICC, ELISA applications with reactivity to human samples\n87317-1-RR targets DHX30 in WB, IF\/ICC, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: HEK-293T cells, U2OS cells,  HuH-7 cells,  HeLa cells,  HCT 116 cells\nPositive IF\/ICC detected in: U2OS cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:5000-1:50000\nImmunofluorescence (IF)\/ICC: IF\/ICC : 1:250-1:1000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nThe DHX30 protein is a crucial member of the DEAH-box RNA helicase family, localized in both the cytoplasm and mitochondria. As a key regulator of RNA metabolism, it hydrolyzes ATP to unwind RNA secondary structures or RNA-protein complexes, thereby playing a central role in fundamental cellular processes such as ribosome biogenesis, mitochondrial translation initiation, and the regulation of mRNA stability.\nThis protein is particularly prominent in the nervous system, where mutations in its encoding gene have been clearly identified as one of the genetic factors leading to neurodevelopmental disorders (such as autism spectrum disorder and intellectual disability), primarily affecting neuronal differentiation and synaptic function. In recent years, studies have also found that DHX30 is abnormally expressed in various cancer tissues, suggesting its potential involvement in tumor development and progression, making it a promising tumor biomarker and therapeutic target.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: CatNo: Ag29885 Product name: Recombinant human DHX30 protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 336-501 aa of BC014237 Sequence: QVRQGKVTRQGKFKPNSVTYRTKSGNILLHKSTINREATRLRSRWLTYFMAVKSNGSVFVRDSSQVHPLAVLLLTDGDVHIRDDGRRATISLSDSDLLRLEGDSRTVWLLKELRRALGRMVERSLRSELAALPPSVQEEHGQLLALLAELLRGPCGSFDVRKTADD Predict reactive species\nFull Name: DEAH (Asp-Glu-Ala-His) box polypeptide 30\nCalculated Molecular Weight: 501 aa, 56 kDa\nObserved Molecular Weight: 134 kDa\nGenBank Accession Number: BC014237\nGene Symbol: DHX30\nGene ID (NCBI): 22907\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: Q7L2E3\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888735670441,"sku":"87317-1-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/proteintech-87317-1-rr","provider":"Iright","version":"1.0","type":"link"}