{"product_id":"proteintech-cl488-66902","title":"Proteintech, CL488-66902, CoraLite® Plus 488-conjugated AIM2 Monoclonal antibody","description":"Size: 100ul\nThe AIM2 (CL488-66902) by Proteintech is a Monoclonal antibody targeting AIM2 in WB, IF\/ICC applications with reactivity to human, mouse, rat, rabbit samples\nCL488-66902 targets AIM2 in WB, IF\/ICC applications and shows reactivity with human, mouse, rat, rabbit samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: RAW 264.7 cells\nPositive IF\/ICC detected in: MCF-7 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:500-1:1000\nImmunofluorescence (IF)\/ICC: IF\/ICC : 1:50-1:500\n\u003cb\u003eBackground Information\u003c\/b\u003e\nAbsent in melanoma 2 (AIM2) is a sensor of cytosolic DNA that is responsible for activation of the inflammasome and host immune responses to DNA viruses and intracellular bacteria [PMID:\n22695634]. Upon binding to DNA, it is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Otherwise, it functions as a tumor suppressor which may act by repressing NF-kappa-B transcriptional activity [PMID:16432157,20566831]. 66902-1-Ig antibody detects the  37-39 and 53 kDa protein in SDS-PAGE similar to the paper published. [PMID: 28809949]\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse, rat, rabbit\nHost \/ Isotype: Mouse \/ IgG1\nClass: Monoclonal\nType: Antibody\nImmunogen: CatNo: Ag14607 Product name: Recombinant human AIM2 protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 1-343 aa of BC010940 Sequence: MESKYKEILLLTGLDNITDEELDRFKFFLSDEFNIATGKLHTANRIQVATLMIQNAGAVSAVMKTIRIFQKLNYMLLAKRLQEEKEKVDKQYKSVTKPKPLSQAEMSPAASAAIRNDVAKQRAAPKVSPHVKPEQKQMVAQQESIREGFQKRCLPVMVLKAKKPFTFETQEGKQEMFHATVATEKEFFFVKVFNTLLKDKFIPKRIIIIARYYRHSGFLEVNSASRVLDAESDQKVNVPLNIIRKAGETPKINTLQTQPLGTIVNGLFVVQKVTEKKKNILFDLSDNTGKMEVLGVRNEDTMKCKEGDKVRLTFFTLSKNGEKLQLTSGVHSTIKVIKAKKKK Predict reactive species\nFull Name: absent in melanoma 2\nCalculated Molecular Weight: 343 aa, 39 kDa\nObserved Molecular Weight: 37-39 and 53 kDa\nGenBank Accession Number: BC010940\nGene Symbol: AIM2\nGene ID (NCBI): 9447\nRRID: AB_3084284\nConjugate: CoraLite® Plus 488 Fluorescent Dye\nExcitation\/Emission Maxima Wavelengths: 493 nm \/ 522 nm\nForm: Liquid\nPurification Method: Protein G purification\nUNIPROT ID: O14862\nStorage Buffer: PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.\nStorage Conditions: Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888085684393,"sku":"CL488-66902","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/proteintech-cl488-66902","provider":"Iright","version":"1.0","type":"link"}