{"product_id":"abcam-ab101278","title":"Abcam, ab101278, Anti-Influenza Virus NS1A Binding Protein antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal Influenza Virus NS1A Binding Protein antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human IVNS1ABP aa 50-100.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human IVNS1ABP aa 50-100. The exact immunogen used to generate this antibody is proprietary information.Q9Y6Y0\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab101278 was affinity purified using an epitope specific to Influenza Virus NS1A Binding Protein immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate\/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle, Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nInfluenza Virus NS1A Binding Protein (IVNS1ABP) also known as NS1-BP is a cellular protein that interacts with the NS1 protein of the influenza virus to modulate viral replication. This interaction suppresses host antiviral responses enhancing influenza virus propagation. IVNS1ABP has a molecular weight of approximately 77 kDa. It expresses mainly in the nucleus and cytoplasm of host cells where it engages with host molecules to facilitate viral protein synthesis and assembly.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nIVNS1ABP contributes to the regulation of protein synthesis pathways and facilitates RNA processing by directly interacting with host machinery. It functions within a complex containing several host proteins that assist in transcriptional control and mRNA splicing. These interactions provide the influenza virus with a supportive environment for efficient propagation effectively avoiding the host's immune defenses.\u003cbr\u003e\nPathways\u003cbr\u003e\nIVNS1ABP operates in the RNA processing and splicing mechanisms that are critical for both host and viral gene expression. The protein forms pathways with host RNA polymerase II and other spliceosomal components influencing the maturation of mRNA precursors. These pathways not only support viral replication but also adjust host cell pathways to prioritize viral transcription over normal cellular processes.\u003cbr\u003e\nIVNS1ABP's modification of host defenses links it directly to influenza pathogenesis and secondary immune suppression. This protein also connects to the nonstructural NS1 protein of the influenza virus an interaction important for evading the host immune response. Understanding IVNS1ABP's role in these pathways helps develop therapeutic strategies for controlling influenza infections targeting its interactions to hinder the viral lifecycle.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850163212457,"sku":"ab101278","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab101278","provider":"Iright","version":"1.0","type":"link"}