{"product_id":"abcam-ab104220","title":"Abcam, ab104220, Anti-SAF-B2 antibody","description":"\u003cp\u003eSize: 50µL\u003cbr\u003e\nRabbit Polyclonal SAF-B2 antibody. Suitable for WB, IHC-P, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SAFB2 aa 350-550.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human SAFB2 aa 350-550. The exact immunogen used to generate this antibody is proprietary information.Q14151\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSAF-B2 also known as Scaffold Attachment Factor B2 is a critical protein in cellular regulation with a molecular weight of approximately 100 kDa. It is widely expressed in the nucleus of various cell types serving a role in transcriptional regulation. As a component of the scaffold\/matrix attachment regions (S\/MARs) it interacts with chromosomal DNA to influence gene expression. This interaction helps in organizing chromosomal structures profoundly impacting gene accessibility and transcription processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSAF-B2 takes part in regulating transcription and RNA processing contributing to its functional versatility. It interacts with several RNA-binding proteins as part of a nuclear protein complex. These interactions suggest SAF-B2’s involvement in RNA splicing and stabilization linking it to mRNA processing pathways. The protein plays an important role in maintaining transcriptional fidelity and ensuring appropriate cellular response to varying signals.\u003cbr\u003e\nPathways\u003cbr\u003e\nSAF-B2 affects transcription and mRNA processing pathways significantly. It associates with proteins like SAF-B which also participate in chromatin remodeling and gene regulation. Both proteins contribute to the regulation of gene expression through their participation in the complex network of transcriptional pathways. Additionally SAF-B2's involvement in signaling pathways indicates its broader role in cellular communication and response modulation.\u003cbr\u003e\nAlterations in SAF-B2 have connections to cancer and neurodegenerative diseases. Aberrant expression or mutation can disrupt normal gene regulation processes contributing to tumorigenesis or neural dysfunction. The protein's interaction with SAF-B highlights the potential for misregulated pathways to promote disease states. Understanding SAF-B2’s role in these processes aids in developing targeted therapeutic strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848632422569,"sku":"ab104220","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab104220","provider":"Iright","version":"1.0","type":"link"}