{"product_id":"abcam-ab104225","title":"Abcam, ab104225, Anti-NeuN antibody - Neuronal Marker","description":"\u003cp\u003eSize: 50µL\u003cbr\u003e\nAnti-NeuN antibody - Neuronal Marker (ab104225) is a rabbit polyclonal antibody detecting NeuN in  Western Blot, IHC-P, IHC-Fr . Suitable for  Human, Mouse, Rat . - Over 250 publications\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:IHC-P, WB, IHC-FoFr, IHC-FrFlSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nAnti-NeuN antibody - Neuronal Marker (ab104225) is a rabbit polyclonal antibody and is validated for use in IHC-FoFr, IHC-FrFl, IHC-P, WB in human samples.\u003cbr\u003e\nAnti-NeuN antibody - Neuronal Marker (ab104225) has been cited over 252 times in peer reviewed journals and is trusted by the scientific community.\u003cbr\u003e\nAbcam's high quality validation processes ensure Anti-NeuN antibody - Neuronal Marker (ab104225) has high sensitivity and specificity.\u003cbr\u003e\nAnti-NeuN antibody - Neuronal Marker (ab104225) has 11 independent reviews from customers.\u003cbr\u003e\nAnti-NeuN antibody - Neuronal Marker (ab104225) specifically detects NeuN (UniProt ID: A6NFN3; Molecular weight: 34kDa) and is sold in 50 µL selling sizes.\u003cbr\u003e\nNeuN (RBFOX3), a protein predominantly found in neuronal nuclei and cytoplasm, serves as a key marker for identifying neurons in research. It plays a significant role in the regulation of alternative splicing of pre-mRNA, crucial for neural development and function. Abnormalities in RBFOX3 expression have been implicated in several neurodevelopmental disorders, such as autism spectrum disorder, cognitive impairments, and epilepsy, underscoring its critical role in brain health.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-Preservative: 0.03% Sodium azideConstituents: PBS, 49.98% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNeuN also known as Fox-3 or Rbfox3 serves as a vital neuronal marker and has a molecular weight of about 46-50 kDa. This nuclear protein is commonly found in neuronal cells in the central nervous system but it does not appear in glial cells. Researchers use NeuN staining as an effective tool to identify neurons in various brain regions due to its reliable expression pattern in mature neurons. The presence of NeuN can be detected using methods such as NeuN IHC (immunohistochemistry) and NeuN Western blot aiding in cellular and tissue analysis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNeuN plays an essential role in the regulation of RNA-binding influencing the splicing and stability of transcripts. It forms part of the complex network responsible for managing neuron-specific gene expression. By interacting with other RNA-binding proteins NeuN contributes to the fine-tuning needed for proper neuronal development and function. As a result NeuN helps maintain the health and activity of nerve cells allowing them to perform complex neurological tasks.\u003cbr\u003e\nPathways\u003cbr\u003e\nNeuN has a significant role in neuronal differentiation and plasticity pathways. NeuN coordinates with elements of the Notch signaling pathway which is important for guiding cell fate decisions in the nervous system. It also interacts with related proteins like Fox proteins involved in splicing regulation. These pathways ensure neurons develop differentiate and function correctly within the nervous system's precise architecture.\u003cbr\u003e\nDisruptions in NeuN expression link closely to neurodegenerative diseases such as Parkinson's disease and Amyotrophic lateral sclerosis (ALS). Abnormal NeuN expression correlates with neuron loss and dysfunction in these conditions with connectivity to other affected proteins like alpha-synuclein in Parkinson's disease. In ALS abnormal NeuN-staining patterns indicate neuronal cell death serving as a potential marker for disease progression. Studying these connections improves our understanding of disease mechanisms and aids in the development of targeted therapies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844215918761,"sku":"ab104225","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab104225","provider":"Iright","version":"1.0","type":"link"}