{"product_id":"abcam-ab104755","title":"Abcam, ab104755, Recombinant Human EEF1D protein","description":"\u003cp\u003eSize: 50µg \/ 250µg\u003cbr\u003e\nRecombinant Human EEF1D protein is a Human Full Length protein, in the 1 to 281 aa range, expressed in Escherichia coli, with \u0026gt;90%, suitable for SDS-PAGE, Mass Spec.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;90% SDS-PAGE,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:His tag N-Terminus,\u003cbr\u003e\nApplications:Mass Spec, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:P29692,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nEEF1D also known as elongation factor 1-delta plays an important role in protein synthesis by facilitating the delivery of aminoacyl-tRNA to the ribosome A-site during translation elongation. The protein has a molecular mass of approximately 33 kDa. EEF1D is expressed in various tissues with notable presence in the heart and skeletal muscle. This expression pattern suggests its involvement in tissue-specific synthesis of proteins needed for diverse cellular functions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nEEF1D interacts with other components of the translational machinery to form the elongation factor complex which is essential for efficient protein biosynthesis. EEF1D's interaction with the EF1B complex supports the recycling of guanine nucleotides which prepares EF1A for reuse in additional rounds of protein elongation. This collaboration within the machinery highlights EEF1D's importance in maintaining proper protein synthesis rates which are important for cellular growth and repair processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nEEF1D is integral in the translation and protein metabolism pathways. The protein's roles align closely with those of EEF1A and EEF1B ensuring smooth continuation of the elongation phase of protein synthesis. Its participation in these pathways highlights how alterations in EEF1D function might disrupt broader cellular processes impacting how cells respond to genetic instructions and manage protein construction workflows.\u003cbr\u003e\nEEF1D has connections to cancer and neurodegenerative diseases. Abnormal expression or mutations in EEF1D can influence tumor progression by altering protein synthesis rates or pathways related to cell proliferation. Additionally connections exist between EEF1D and EEF1A2 in neurodegenerative conditions where disruptions in protein synthesis contribute to neuronal damage and disease manifestation. Understanding EEF1D's role in these conditions may offer insight into potential therapeutic targets for intervention.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844022161577,"sku":"ab104755","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab104755","provider":"Iright","version":"1.0","type":"link"}