{"product_id":"abcam-ab105393","title":"Abcam, ab105393, Anti-PIWIL1 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal PIWIL1 antibody. Suitable for WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human PIWIL1 aa 50-150.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human PIWIL1 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.Q96J94,\u003cbr\u003e\nSpecificity:At least three isoforms of PIWIL1 are known to exist; ab105393 will recognize the two longest isoforms. ab105393 is predicted to not cross-react with other PIWI family members.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPIWIL1 also known as Piwi-like protein 1 is a member of the Argonaute family with a molecular mass of approximately 97 kDa. This protein functions mechanically by binding to PIWI-interacting RNAs (piRNAs) which are small non-coding RNAs. PIWIL1 exhibits expression in germline cells specifically in testes therefore playing an important role in spermatogenesis. It facilitates the formation of piRNA complexes contributing to the regulation of gene silencing.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPIWIL1 contributes to maintaining genomic integrity through its role in RNA-mediated gene regulation. It forms part of the piRNA-induced silencing complex. This complex targets transposable elements and prevents their mobility an important function for genomic stability. PIWIL1's involvement in gametogenesis highlights its essential function in reproductive biology and cellular processes where piRNA pathways operate.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe PIWIL1 protein plays significant roles within the piRNA pathway which is important for transposon silencing and germline integrity. PIWIL1 interacts with MILI and MIWI two proteins that also participate in the silencing of transposable elements. This pathway intersects with other gene regulation pathways influencing the overall expression landscape necessary for proper cellular function in reproductive tissues.\u003cbr\u003e\nPIWIL1 alterations have associations with germ cell tumors and fertility issues. Disruption in piRNA pathway components like PIWIL1 and its partners MIWI and MILI can lead to failures in genomic defense mechanisms influencing cancer development in germline cells. Additionally defects in PIWIL1 expression can contribute to infertility due to its role in spermatogenesis. Understanding these associations provides insights into potential diagnostic and therapeutic targets for related conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850118156457,"sku":"ab105393","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab105393","provider":"Iright","version":"1.0","type":"link"}