{"product_id":"abcam-ab10881","title":"Abcam, ab10881, Anti-Cig2 antibody [CIG 3A11\/5]","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Monoclonal CG22 antibody. Suitable for IP, ELISA and reacts with Schizosaccharomyces pombe samples. Cited in 4 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:CIG 3A11\/5,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Schizosaccharomyces pombe,\u003cbr\u003e\nApplications:IP, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCig2 also known as Cdc13 cyclin is a protein with a mass of around 60 kDa. It functions mechanically as an important regulator of the cell cycle particularly in the initiation of DNA replication. Cig2 is part of a family of cyclins and is expressed predominantly in fission yeast Schizosaccharomyces pombe. The protein forms a complex with Cdc2 to regulate the S phase entry of the cell cycle.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCig2 helps control the timing for the initiation of DNA replication contributing to genome stability. Cig2 interacts with Cdc2 kinase to form an active complex that facilitates cell cycle progression ensuring accurate replication processes. The coordination within this complex allows the cell to transition from the G1 phase to S phase monitoring and controlling the replication machinery.\u003cbr\u003e\nPathways\u003cbr\u003e\nCig2 holds a significant role within the cell cycle regulatory mechanisms. It participates in the regulation of the S phase entry within the well-known cyclin-dependent kinase pathway. Cig2 primarily interacts with Cdc2 but it also influences the activity of other related cyclins such as Cig1 which together contribute to the control of cellular division and replication. This cyclin-dependent regulation ensures a tightly controlled cell cycle progression.\u003cbr\u003e\nAbnormalities in Cyclin-dependent kinase pathways involving Cig2 might lead to replication stress contributing to oncogenic transformations. Although Cig2 itself is studied mainly in yeast it provides insights into cyclin mechanisms relevant to cancer development in higher organisms. Furthermore disruptions in the regulatory interplay involving Cig2 and Cdc2 can manifest in misregulated cell growth leading to proliferative disorders. Understanding the interactions between these proteins is valuable for developing potential therapeutic targets for cancer treatment.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855347372201,"sku":"ab10881","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab10881","provider":"Iright","version":"1.0","type":"link"}