{"product_id":"abcam-ab110264","title":"Abcam, ab110264, Anti-COX6A2 antibody [4H2A5]","description":"\u003cp\u003eSize: 250µg\u003cbr\u003e\nMouse Monoclonal COX6A2 antibody. Suitable for WB and reacts with Cow samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:4H2A5,\u003cbr\u003e\nIsotype:IgG2b,\u003cbr\u003e\nLight chain type:kappa,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Cow,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWant a custom formulation?\u003cbr\u003e\nThis antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-IgG fraction, Purification notes-Near homogeneity as judged by SDS-PAGE. ab110264 was produced in vitro using hybridomas grown in serum-free medium, and then purified by biochemical fractionation., Storage buffer-pH: 7.5Preservative: 0.02% Sodium azideConstituents: HEPES buffered saline, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\n`COX6A2` also known as cytochrome c oxidase subunit 6A2 is a component of the cytochrome c oxidase complex which is part of the electron transport chain. This protein weighs approximately 9 kDa. It is mainly expressed in muscle tissues both cardiac and skeletal reflecting its significant role in tissues with high energy demands. The `COX6A2` protein contributes to the proper functioning of cytochrome c oxidase aiding in the efficient transfer of electrons from cytochrome c to oxygen the final electron acceptor in the chain.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\n`COX6A2` participates in energy production within cells by facilitating mitochondrial oxidative phosphorylation. It is part of the cytochrome c oxidase complex which consists of multiple subunits each playing a unique role in electron transport and proton pumping to generate a proton gradient across the mitochondrial membrane. This proton gradient is essential for ATP synthesis. The activity of `COX6A2` supports normal mitochondrial function and energy homeostasis especially in cells with heavy metabolic requirements.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe function of `COX6A2` integrates into the mitochondrial respiratory chain specifically in the oxidative phosphorylation pathway. This pathway is important for ATP generation an important process for cellular energy supplies. Additionally `COX6A2` is associated with the regulation of the apoptosis pathway as disruptions in the respiratory chain can trigger programmed cell death. The function of cytochrome c and subunit interactions underline these pathways with each having pivotal roles in maintaining cellular metabolism and survival.\u003cbr\u003e\nDisruptions in `COX6A2` activity relate to mitochondrial diseases such as cytochrome c oxidase deficiency which can lead to severe metabolic complications. This deficiency affects energy production in muscles and other tissues by impairing the electron transport chain. Additionally mutations or malfunctions involving `COX6A2` may have links to cardiac disorders due to its strong expression in cardiac muscle. The alteration in `COX6A2` can impact the function of related proteins such as those included in the mitochondrial respiratory chain ultimately affecting energy-dependent tissues and processes.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855422181545,"sku":"ab110264","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab110264","provider":"Iright","version":"1.0","type":"link"}