{"product_id":"abcam-ab111912","title":"Abcam, ab111912, Anti-Somatostatin 28 antibody [EPR3359(2)]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nAnti-Somatostatin 28 antibody [EPR3359(2)] (ab111912) is a rabbit monoclonal antibody detecting Somatostatin 28 in  IHC-P, IHC-Fr, mIHC . Suitable for  Human, Mouse, Rat . - KO validated for confirmed specificity - Multiplex IHC validated on the Leica BOND® MAX using Opal reagents - Biophysical QC for unrivalled batch-batch consistency\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR3359(2),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:IHC-P, mIHC, IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-Somatostatin 28 antibody [EPR3359(2)] (ab111912) is a rabbit recombinant monoclonal antibody and is validated for use in Immunohistochemistry (IHC-P), Immunohistochemistry (IHC-Fr), Multiplex IHC (mIHC) in Human, Mouse, Rat samples.\u003cbr\u003e\nTrial sizes available!\u003cbr\u003e\nTest your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl.\u003cbr\u003e\nDiscover our selection of trial-size antibodies\u003cbr\u003e\nSpecificity confirmed\u003cbr\u003e\nThe specificity of Anti-Somatostatin 28 antibody [EPR3359(2)] (ab111912) has been confirmed by Immunohistochemistry (Formalin\/PFA-fixed paraffin-embedded sections) testing in Somatostatin Knockout Mouse Brain samples.\u003cbr\u003e\nOther related products\u003cbr\u003e\nWe have a range of other formats of antibody clone [EPR3359(2)] also available for your convenience: ab111912, Carrier free -\u003cbr\u003e\nab227422\u003cbr\u003e\n, Alexa Fluor® 488 -\u003cbr\u003e\nab311011\u003cbr\u003e\n, Alexa Fluor® 647 -\u003cbr\u003e\nab311139\u003cbr\u003e\n, Alexa Fluor® 594 -\u003cbr\u003e\nab311776\u003cbr\u003e\n, Alexa Fluor® 568 -\u003cbr\u003e\nab313057\u003cbr\u003e\n, Alexa Fluor® 555 -\u003cbr\u003e\nab313257\u003cbr\u003e\n, Alexa Fluor® 750 -\u003cbr\u003e\nab320968\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSomatostatin 28 also known as SST-28 is a biologically active peptide that functions as a hormone. It is an alternate form of somatostatin the other being somatostatin-14. Somatostatin 28 is characterized by its longer peptide chain with a molecular mass of approximately 3.2 kDa. This peptide is expressed mainly in the central nervous system particularly in the hypothalamus and in the gastrointestinal tract. Its synthesis involves specific posttranslational processing steps and it acts in various cellular locations performing regulatory roles in endocrine and exocrine systems.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSomatostatin 28 plays an important role in inhibiting the release of certain hormones and neurotransmitters. It exerts its effects by binding to specific somatostatin receptors which are part of a family of G-protein-coupled receptors. These receptors when activated by somatostatin 28 can inhibit adenylyl cyclase activity reducing cyclic AMP levels and therefore suppressing hormone secretion. While somatostatin 28 does not form part of a large multi-protein complex it acts collaboratively with related peptides and receptors to modulate neuronal and digestive functions.\u003cbr\u003e\nPathways\u003cbr\u003e\nSomatostatin 28 participates centrally in the regulation of the endocrine signaling pathways notably influencing the growth hormone inhibitory pathway. This pathway involves interconnected proteins such as growth hormone-releasing hormone (GHRH) which somatostatin 28 suppresses. Additionally the peptide plays a role in modulating the insulin signaling pathway where it inhibits the secretion of insulin. These pathways highlight somatostatin 28's regulatory influence on metabolism and cellular growth by interacting with other proteins like insulin and GHRH.\u003cbr\u003e\nSomatostatin 28 is implicated in conditions such as acromegaly and certain types of diabetes. In acromegaly excessive growth hormone production often due to pituitary adenomas is counteracted by somatostatin 28's inhibitory effects. The peptide's interaction with the receptor-bound growth hormone contributes to potential therapeutic approaches to managing this disorder. In diabetes specifically type 2 somatostatin 28's role in inhibiting insulin release provides insight into its involvement in glucose metabolism dysregulation. Understanding these connections highlights the importance of somatostatin 28 and related proteins like insulin in the pathophysiology of metabolic diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844058009769,"sku":"ab111912","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab111912","provider":"Iright","version":"1.0","type":"link"}