{"product_id":"abcam-ab112304","title":"Abcam, ab112304, Recombinant Human HYAL1 protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human HYAL1 protein is a Human Full Length protein, in the 1 to 253 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:WB, ELISA, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q12794,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is useful for Antibody Production and Protein Array.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHYAL1 also known as hyaluronidase-1 functions as an enzyme that catalyzes the degradation of hyaluronic acid into smaller oligosaccharides. It possesses a mass of approximately 57 kDa. This enzyme is expressed in various tissues including the liver spleen and kidney. HYAL1 plays an essential role in the turnover of extracellular matrix components impacting tissue remodeling and cell migration.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nHyaluronidase-1 facilitates the breakdown of hyaluronic acid a major component of the extracellular matrix affecting cellular interactions and signaling pathways. HYAL1 does not operate as part of a protein complex but acts individually. Its enzymatic activity influences processes such as cell proliferation tissue repair and inflammatory response as hyaluronic acid fragments modulate these cellular behaviors.\u003cbr\u003e\nPathways\u003cbr\u003e\nHyaluronidase-1 engages in significant pathways involved in extracellular matrix organization and degradation. It interacts within the hyaluronan metabolism pathway impacting proteins like CD44 and RHAMM which are involved in cell adhesion and motility. By processing hyaluronic acid HYAL1 affects these pathways influencing cellular dynamics and homeostasis.\u003cbr\u003e\nAbnormal HYAL1 function associates with conditions such as cancer and osteoarthritis. In cancer increased hyaluronidase-1 activity correlates with tumor progression and metastasis as it promotes cancer cell invasion through the extracellular matrix. In osteoarthritis enzymatic degradation of hyaluronic acid disrupts cartilage integrity exacerbating disease symptoms. Additionally the interaction of hyaluronidase-1 with proteins like CD44 in these conditions may further drive pathological changes.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843876802729,"sku":"ab112304","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab112304","provider":"Iright","version":"1.0","type":"link"}