{"product_id":"abcam-ab113119","title":"Abcam, ab113119, Recombinant human PPIL3 protein","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRecombinant human PPIL3 protein is a Human Full Length protein, in the 1 to 161 aa range, expressed in Escherichia coli, with \u0026gt;90%, suitable for SDS-PAGE, Mass Spec, FuncS.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;90% SDS-PAGE,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:His tag N-Terminus,\u003cbr\u003e\nApplications:FuncS, SDS-PAGE, Mass SpecSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:Yes,\u003cbr\u003e\nBiological activity:Specific activity is \u0026gt; 280 nmoles\/min\/mg, and is defined as the amount of enzyme that cleaves 1 μmole of suc-AAPF-pNA per minute at 37°C in Tris-Hcl pH8.0 using chymotrypsin.,\u003cbr\u003e\nAccession:Q9H2H8,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 20% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPPIL3 or Peptidylprolyl isomerase (cyclophilin)-like 3 is an enzyme that assists in protein folding by catalyzing the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. It weighs approximately 52 kDa. PPIL3 expression can be found in various tissues including liver and thymus. The protein acts as a member of the cyclophilin family which is known for its role in protein folding and immunosuppression.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe function of PPIL3 includes its contribution to the assembly of spliceosomal complexes. It interacts with other proteins to aid the splicing of pre-mRNA therefore influencing gene expression regulation. Though PPIL3 operates independently it often localizes within multiprotein complexes involved in RNA processing. Its role in the spliceosome highlights its importance in the accurate and efficient editing of RNA transcripts.\u003cbr\u003e\nPathways\u003cbr\u003e\nPPIL3 participates in the RNA splicing and gene expression pathways. Within these pathways PPIL3 shows interactions with the spliceosomal proteins such as U2 small nuclear ribonucleoprotein highlighting its contribution to mRNA splicing regulation. It involves itself in adjusting the splicing machinery's fine-tuning ensuring correct mRNA processing essential for cellular functions.\u003cbr\u003e\nPPIL3 has links to conditions such as cancer and neurodegeneration. Its role in RNA splicing means that any dysfunction resulting in spliceosomal assembly errors can contribute to diseases like cancer where incorrect mRNA splicing leads to aberrant gene expression. PPIL3 is also associated with cyclophilin B through their overlapping functions in protein folding and transport which can become impaired in neurodegenerative disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843927396521,"sku":"ab113119","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab113119","provider":"Iright","version":"1.0","type":"link"}