{"product_id":"abcam-ab113413","title":"Abcam, ab113413, Anti-SDF4 antibody","description":"\u003cp\u003eSize: 200µL\u003cbr\u003e\nGoat Polyclonal SDF4 antibody. Suitable for IHC-P, WB, Flow Cyt, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SDF4 aa 150-200.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Goat,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, Flow Cyt, ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human SDF4 aa 150-200. The exact immunogen used to generate this antibody is proprietary information.Q9BRK5,\u003cbr\u003e\nSpecificity:ab113413 is expected to recognize both reported isoforms (NP_057631.1; NP_057260.2).\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab11343 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 99% Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSDF4 also known as Stromal Cell Derived Factor 4 or Cab45 is a calcium-binding protein with a molecular mass of approximately 45 kDa. It is expressed in the Golgi apparatus of cells in various tissues including pancreas liver and brain. SDF4 plays a mechanical role in sorting and trafficking of proteins through the secretory pathway specifically during the transport of secretory cargo in the Golgi.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein participates in the regulation of calcium-dependent vesicle transport. It does not function as part of a large protein complex but interacts with different proteins in the Golgi for sorting activities. SDF4's ability to bind calcium allows it to modulate interactions necessary for vesicle movement and cargo recognition affecting how proteins exit the Golgi and are distributed to other areas of the cell.\u003cbr\u003e\nPathways\u003cbr\u003e\nStudies show SDF4 is involved in the cellular secretory pathway and calcium signaling pathway. Within these pathways SDF4 interacts with proteins like co-chaperone SIL1 to ensure proper protein folding and trafficking. SDF4 also contributes to vesicle budding processes that are essential for maintaining proper cellular function and homeostasis.\u003cbr\u003e\nDysfunction of SDF4 links to disorders such as diabetes and neurodegenerative diseases. Abnormal SDF4 expression impacts proteins like insulin in the pancreatic pathway contributing to diabetes through misfolding or improper secretion of insulin. In neurodegenerative conditions SDF4's disrupted association with proteins involved in calcium homeostasis affects synaptic function and neuron health implicating it in diseases like Alzheimer's.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854454804649,"sku":"ab113413","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab113413","provider":"Iright","version":"1.0","type":"link"}