{"product_id":"abcam-ab113684","title":"Abcam, ab113684, Anti-VMA2 antibody [13D11B2]","description":"\u003cp\u003eSize: 250µg\u003cbr\u003e\nMouse Monoclonal VMA2 antibody. Suitable for WB, ICC\/IF and reacts with Saccharomyces cerevisiae samples. Cited in 3 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:13D11B2,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nLight chain type:kappa,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Saccharomyces cerevisiae,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWant a custom formulation?\u003cbr\u003e\nThis antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Proprietary technique, Purification notes-Near homogeneity as judged by SDS-PAGE (purity \u0026gt;95%). The antibody was produced in vitro using hybridomas grown in serum-free medium, and then purified by biochemical fractionation., Storage buffer-pH: 7.5Preservative: 0.02% Sodium azideConstituents: HEPES buffered saline, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nVMA2 also known as V-type proton ATPase subunit B enzyme plays a role in the assembly and function of the V-ATPase complex that acidifies cellular compartments. This protein has a mass of approximately 57 kDa. VMA2 localizes to membrane structures and is expressed highly in yeast and other eukaryotic organisms. Its main role is maintaining the proton gradient across the vacuolar membrane influencing several cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nVMA2 functions as part of the V-ATPase complex which is essential for cellular energy regulation and the acidification of vacuoles and endosomes. This complex contributes to cellular homeostasis by facilitating pH regulation and ion transport. VMA2 as a non-catalytic subunit assists with the stabilization of the enzyme structure and participates in proton transport processes that impact numerous cellular activities.\u003cbr\u003e\nPathways\u003cbr\u003e\nVMA2 influences protein sorting and vesicle trafficking within the endocytic and secretory pathways. It collaborates with proteins like VMA9 and VMA13 to regulate these processes. The function of the V-ATPase complex including VMA2 integrates into pathways like the pH signaling pathway and vesicular trafficking ensuring proper cellular functions like nutrient uptake and protein degradation.\u003cbr\u003e\nVMA2 has been linked to conditions like osteopetrosis and Fanconi syndrome. These disorders relate to improper acidification due to dysfunctional V-ATPase. VMA2's association with VMA4 and other V-ATPase components becomes important in understanding the molecular basis of these diseases shedding light on possible therapeutic targets or disease markers.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854748831913,"sku":"ab113684","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab113684","provider":"Iright","version":"1.0","type":"link"}