{"product_id":"abcam-ab11436","title":"Abcam, ab11436, Anti-PSMD7\/Mov34 antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nRabbit Polyclonal PSMD7\/Mov34 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human PSMD7 aa 50-100.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human PSMD7 aa 50-100. The exact immunogen used to generate this antibody is proprietary information.P51665\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe PSMD7 protein also known as Mov34 is a subunit of the 26S proteasome and plays an important role in protein degradation. The proteasome itself is a massive complex and PSMD7 is a 37 kDa protein component. Its primary site of expression is within the cytoplasm and nucleus of cells where it facilitates the breakdown of ubiquitinated proteins. This activity is essential for maintaining cellular protein homeostasis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe proper function of PSMD7 supports cell cycle regulation apoptosis and DNA damage repair. It exists as part of the 26S proteasome complex which is responsible for the regulated degradation of ubiquitin-conjugated proteins. This process controls various cellular mechanisms by ensuring that proteins are broken down after they have executed their function or if they become misfolded or damaged.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe involvement of PSMD7 in proteolysis is central for processes such as the ubiquitin-proteasome pathway. This pathway is critical for protein turnover and the regulation of cellular processes including the cell cycle. PSMD7 works in tandem with other proteasomal subunits like PSMD4 and PSMD14 which help recruit and process ubiquitinated substrates.\u003cbr\u003e\nThe malfunction of PSMD7 associates with certain cancers and neurodegenerative diseases. Aberrations in proteasome function involving PSMD7 may lead to the accumulation of damaged proteins which contributes to cancer development through unchecked cell proliferation. In neurodegenerative disorders like Alzheimer's disease proteins like tau and beta-amyloid which should normally be degraded accumulate due to proteasomal dysfunction involving PSMD7.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854138495145,"sku":"ab11436","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab11436","provider":"Iright","version":"1.0","type":"link"}