{"product_id":"abcam-ab114381","title":"Abcam, ab114381, Recombinant Human GRPR protein","description":"\u003cp\u003eSize: 2µg\u003cbr\u003e\nRecombinant Human GRPR protein is a Human Full Length protein, in the 1 to 384 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:ELISA, WB, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:P30550,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.3% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe gastrin-releasing peptide receptor (GRPR) also known as the bombesin receptor subtype 2 (BB2) is a G protein-coupled receptor. It has a mass of approximately 44 kDa. GRPR expresses mainly in the central nervous system including the brain and also in peripheral tissues like the pancreas and the lungs. This receptor binds to gastrin-releasing peptide (GRP) which is a regulatory molecule involved in various physiological processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGRPR activates intracellular signaling pathways leading to changes in cellular activity. This includes influencing the release of hormones neurotransmitters and intestinal peptides. It is part of a signaling complex that plays roles in neuroendocrine regulation and smooth muscle contraction. GRPR also participates in the regulation of cell proliferation and migration making it an important component in both normal and pathological physiology.\u003cbr\u003e\nPathways\u003cbr\u003e\nGRPR integrates into the mitogen-activated protein kinase (MAPK) cascade and the phospholipase C (PLC) pathway. These pathways regulate various functions like cell division and differentiation. GRPR closely interacts with proteins such as protein kinase C (PKC) and extracellular signal-regulated kinases (ERK) enhancing its function in those pathways. This receptor's signaling contributes significantly to cellular communication and response to external stimuli.\u003cbr\u003e\nGRPR shows strong associations with certain cancers like lung cancer and prostate cancer. Its overexpression often leads to increased cell proliferation and survival contributing to oncogenesis. Additionally GRPR has connections with autism spectrum disorders where altered GRPR signaling impacts neurodevelopment. GRPR involvement extends to links with proteins like neuropeptides and other G protein-coupled receptors which play roles in these disease contexts making it an important target for therapeutic interventions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843894857897,"sku":"ab114381","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab114381","provider":"Iright","version":"1.0","type":"link"}