{"product_id":"abcam-ab114634","title":"Abcam, ab114634, Recombinant Human HOXA5 protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human HOXA5 protein is a Human Fragment protein, in the 24 to 113 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:Tag free,\u003cbr\u003e\nApplications:WB, ELISA, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:P20719,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.3% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe HOXA5 protein is a transcription factor known for its role in regulating gene expression. Alternate names include Homeobox A5 and it belongs to the cluster of homeobox genes. HOXA5 has a molecular mass of approximately 30 kDa. This protein is expressed in various tissues including the lungs kidneys and the developing spinal cord. Its expression shows spatial and temporal specificity during embryonic development.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nIt functions as a part of the larger HOX family which comprises transcription factors that orchestrate body plan and segmentation. HOXA5 impacts cell differentiation and organogenesis. It modulates signaling pathways affecting processes like apoptosis and angiogenesis by activating or repressing genes depending on its expression level and cellular context.\u003cbr\u003e\nPathways\u003cbr\u003e\nIt plays a critical role in the Wnt pathway by interacting with secreted proteins that regulate the pathway. Additionally it intersects with the TGF-beta signaling cascade contributing to tissue morphogenesis. These pathways dictate the function and interaction of HOXA5 with proteins like beta-catenin and SMADs. Such interactions ultimately influence cell fate decisions and tissue remodeling.\u003cbr\u003e\nIts deregulation has been implicated in the pathogenesis of lung cancer through its effects on cell proliferation and apoptosis. In congenital diaphragmatic hernia HOXA5's role in normal diaphragm development becomes evident when its function is compromised. The dysregulated expression of HOXA5 often shows linkage with proteins such as p53 highlighting a shared pathway contributing to oncogenic events.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843874377897,"sku":"ab114634","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab114634","provider":"Iright","version":"1.0","type":"link"}