{"product_id":"abcam-ab114654","title":"Abcam, ab114654, Recombinant Human EPB41 protein","description":"\u003cp\u003eSize: 2µg\u003cbr\u003e\nRecombinant Human EPB41 protein is a Human Full Length protein, in the 1 to 720 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:Tag free,\u003cbr\u003e\nApplications:ELISA, WB, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:P11171,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.3% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nProtein 4.1 also known as EPB41 plays an important role in maintaining the mechanical stability and elasticity of the erythrocyte membrane. This protein exists as a component of the erythrocyte membrane skeleton where it interacts with spectrin and actin contributing to the cytoskeletal network. It weighs approximately 80kDa. EPB41 expression is not limited to erythrocytes; it's found in various tissues including the brain and kidney which indicates its diverse functional roles.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe protein supports cell shape and mechanical properties by linking the cytoskeleton to the plasma membrane. EPB41 is involved in the membrane-cytoskeletal junctional complex where it interacts with other proteins such as spectrin and glycophorin C. This interaction is key in erythrocytes to prevent cell lysis under mechanical stress. Beyond its role in erythrocytes EPB41 assists in protein stabilization and localization within the plasma membrane in other cell types.\u003cbr\u003e\nPathways\u003cbr\u003e\nEPB41 plays an important part in the erythrocyte cell surface structure pathway as well as cell signaling pathways in non-erythroid cells. In the former EPB41 works closely with spectrin and actin to maintain the cellular integrity necessary for oxygen transport. Furthermore in cell signaling pathways its interaction with ankyrin influences membrane organization and signal transduction which are vital for diverse cellular functions.\u003cbr\u003e\nMutations or malfunctions in EPB41 correlate with conditions such as hereditary elliptocytosis and neurodegenerative disorders. Hereditary elliptocytosis results from defects in erythrocyte membrane proteins where EPB41 interplays with spectrin to contribute to the disorder. In neurodegenerative diseases alterations in EPB41 may affect brain tissue stability and function due to its role in sustaining membrane mechanics.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843874181289,"sku":"ab114654","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab114654","provider":"Iright","version":"1.0","type":"link"}