{"product_id":"abcam-ab115027","title":"Abcam, ab115027, Anti-ELL2 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal ELL2 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human RNA polymerase II elongation factor ELL2 aa 400-450.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human RNA polymerase II elongation factor ELL2 aa 400-450. The exact immunogen used to generate this antibody is proprietary information.O00472\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab115027 was affinity purified using an epitope specific to ELL2 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate\/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nELL2 also known as Eleven Nineteen Lysine-rich Leukemia 2 is a protein involved in transcriptional regulation. This protein has a molecular mass of approximately 76 kDa. ELL2 is expressed in various tissues including both lymphoid and non-lymphoid origins. It functions as an elongation factor for RNA polymerase II modulating the rate of transcription elongation by directly interacting with the transcription machinery.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nELL2 plays a significant role in RNA processing and maturation. It is a part of the ELL complex and works alongside other proteins that facilitate the transition from transcription initiation to elongation. By promoting RNA synthesis and elongation efficiency ELL2 is linked with gene expression regulation particularly within the adaptive immune system. This protein helps in optimizing the output of genes active in immune cells contributing to the functionality and differentiation of these cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nELL2 participates actively in the transcription regulation pathway and its interaction with RNA polymerase II. The protein influences gene expression regulation by enhancing transcriptional elongation. ELL2 is also involved in pathways associated with the immunoglobulin production process. It interacts with other proteins such as ELL1 and pTEFb which further coordinate the elongation steps of transcription thereby impacting overall gene expression in immune-related pathways.\u003cbr\u003e\nELL2 associates with multiple myeloma and immunodeficiency disorders. Its dysfunction can impact immunoglobulin transcription in plasma cells potentially leading to aberrant immunoglobulin production—an element in the pathogenesis of multiple myeloma. The association of ELL2 with RNA polymerase II and its partners like pTEFb sheds light on its role in these conditions as faulty regulation of transcription elongation can lead to abnormal cell proliferation and survival characteristic of certain cancers and immune disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854021152937,"sku":"ab115027","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab115027","provider":"Iright","version":"1.0","type":"link"}