{"product_id":"abcam-ab115539","title":"Abcam, ab115539, Anti-LASS6\/CERS6 antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nRabbit Polyclonal LASS6\/CERS6 antibody. Suitable for IHC-P, ELISA, WB and reacts with Mouse, Human, Rat samples. Cited in 3 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:IHC-P, WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:ab115539 is predicted not to cross-react with LASS5.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nLASS6 also known as CERS6 is a member of the ceramide synthase family which are enzymes involved in sphingolipid metabolism. CERS6 has a protein mass of approximately 44 kDa. The enzyme is predominantly expressed in the brain liver and kidneys. It operates by catalyzing the formation of ceramides with specific acyl chains playing a role in sphingolipid biosynthesis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCERS6 is involved in the synthesis of longer-chain ceramides which impacts cell membrane structure and signaling. CERS6 performs its function alone and not as part of a larger complex. The enzyme's activity influences cellular processes such as proliferation differentiation and apoptosis contributing to cellular homeostasis. Ceramides produced by CERS6 affect membrane properties and have roles in signal transduction pathways.\u003cbr\u003e\nPathways\u003cbr\u003e\nCERS6 is an important player in the sphingolipid metabolism pathway affecting lipid signaling and apoptosis regulation. This enzyme collaborates with other ceramide synthases such as CERS2 in maintaining balance in ceramide levels influencing cell fate decisions. It also participates in interconnected pathways like the endoplasmic reticulum stress response interacting with proteins such as PERK to modulate apoptosis under stress conditions.\u003cbr\u003e\nCERS6 shows a connection with cancer and neurological disorders. Its altered expression or activity links to tumorigenesis affecting cell growth and survival through interactions with proteins such as p53. In neurological diseases misregulation of CERS6 influences neurodegenerative processes potentially linking to proteins involved in neuroinflammation and cell death. Understanding CERS6's role in these diseases aids in designing therapeutic strategies targeting ceramide metabolism.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854371737769,"sku":"ab115539","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab115539","provider":"Iright","version":"1.0","type":"link"}