{"product_id":"abcam-ab11575","title":"Abcam, ab11575, Anti-Laminin antibody","description":"\u003cp\u003eSize: 125µL\u003cbr\u003e\nAnti-Laminin antibody (ab11575) is a rabbit polyclonal antibody detecting Laminin in  IHC-P, Dot Blot . Suitable for  Human, Mouse . - Over 640 publications - Trusted since 2004\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:Dot, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Native Full Length Protein corresponding to Human LAMA1.P25391,\u003cbr\u003e\nSpecificity:In dot blot immunoassay this antibody does not react with Fibronectin, Vitronectin, Collagen IV, or Chondroitin sulfate types A, B, and C.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nAnti-Laminin antibody (ab11575) is a rabbit polyclonal antibody and is validated for use in Dot and IHC-P.\u003cbr\u003e\nAnti-Laminin antibody (ab11575) was first used in a scientific publication in 2005 and has been cited over 647 times in peer reviewed journals. It's performance in IHC and Western Blot in human, mouse and rat samples is trusted by the scientific community.\u003cbr\u003e\nAbcam's high quality validation processes ensure Anti-Laminin antibody (ab11575) has high sensitivity and specificity.\u003cbr\u003e\nAnti-Laminin antibody (ab11575) has 73 independent reviews from customers.\u003cbr\u003e\nAnti-Laminin antibody (ab11575) specifically detects Laminin (UniProt ID: Q9Y6N6; Molecular weight: 170kDa) and is sold in 125 µL selling sizes.\u003cbr\u003e\nLaminin is a crucial glycoprotein found in the extracellular matrix, essential for the structural integrity and function of basement membranes in all animals. Composed of three distinct polypeptide chains (α, β and γ), laminin forms a cross-shaped molecule that facilitates cell adhesion, differentiation, migration and tissue maintenance. Its role in biological activity makes laminin vital for understanding cellular interactions and tissue organization. Researchers study laminin to gain insights into various physiological processes and pathological conditions, including muscular dystrophy (DMD, BMD) and kidney diseases.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.097% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nLaminin also known as Laminin-1 is a high-molecular weight protein with a mass of approximately 400 to 900 kDa. It belongs to the family of heterotrimeric glycoproteins found in the extracellular matrix specifically within the basement membranes. This protein includes several isoforms referred to as laminins which consist of three distinct chains: α, β and γ. Laminins contribute to the structural scaffolding by interacting with other molecules like collagen and integrins playing a significant role in tissue architecture and cellular activities such as adhesion and migration. Researchers focus on targeting laminin with laminin antibodies for experiments like laminin IHC and laminin staining to visualize and study tissue structures.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nLaminins serve as essential components in maintaining tissue integrity and functions. They form complexes with other matrix elements to establish basement membranes which separate epithelial cells from connective tissue. Laminins interact with cellular receptors influencing cell differentiation movement and growth. Anti-laminin tools like laminin antibodies and laminin staining techniques help identify specific isoforms and analyze their distribution in research. Scientists often utilize laminine products for such purposes including insights into how they might regulate cellular environments through these complexes.\u003cbr\u003e\nPathways\u003cbr\u003e\nLaminins integrate into essential biological pathways including the PI3K\/Akt and MAPK pathways. Through these pathways laminins directly influence cellular processes such as proliferation and survival. They work in tandem with proteins like integrins and collagen reinforcing the structural and signaling pathways necessary for controlling cell fate. These interactions place laminins at the center of cellular communication networks regulating various developmental and physiological processes.\u003cbr\u003e\nLaminins have connections to several medical conditions including muscular dystrophy and certain forms of cancer. Abnormalities in laminin expression or structure can lead to defective basement membranes contributing to genetic disorders like congenital muscular dystrophy. Laminins also interact with collagen another protein involved in maintaining tissue integrity making their dysfunction a point of interest in oncological research. Scientists in laminine UK and globally use anti-laminin technologies to understand laminin's role in pathogenesis aiming to develop targeted therapies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848442204329,"sku":"ab11575","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab11575","provider":"Iright","version":"1.0","type":"link"}