{"product_id":"abcam-ab1168","title":"Abcam, ab1168, PE Anti-CD19 antibody [CB19]","description":"\u003cp\u003eSize: 50Test\u003cbr\u003e\nAnti-CD19 antibody [CB19] - PE conjugated (ab1168) is a mouse monoclonal antibody detecting CD19 in  Flow Cytometry . Suitable for  Chimpanzee, Human, Macaque monkey, Rhesus monkey . - Trusted since 2002\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:CB19,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nLight chain type:unknown,\u003cbr\u003e\nConjugation:PE,\u003cbr\u003e\nExcitation\/Emission:Ex: 480;565nm, Em: 578nm,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Rhesus monkey, Macaque monkey, Chimpanzee,\u003cbr\u003e\nApplications:Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Cell preparation containing CD19 protein. The exact immunogen used to generate this antibody is proprietary information.P15391\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nPE Anti-CD19 antibody [CB19] (ab1168) is a mouse monoclonal antibody and is validated for use in Flow Cytometry (Flow Cyt) in Chimpanzee, Human, Macaque monkey, Rhesus monkey samples.\u003cbr\u003e\nRelated products\u003cbr\u003e\nAntibody clone CB19 is also available pre-conjugated to a variety of labels for your convenience – Anti-CD19 PE [CB19] (ab1168).\u003cbr\u003e\nOther related products\u003cbr\u003e\nWe have a range of other formats of antibody clone [CB19] also available for your convenience:\u003cbr\u003e\nab254170\u003cbr\u003e\n, Carrier free -\u003cbr\u003e\nab255925\u003cbr\u003e\n, Alexa Fluor® 647 -\u003cbr\u003e\nab307266\u003cbr\u003e\n, FITC -\u003cbr\u003e\nab1167\u003cbr\u003e\n, PE - ab1168\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Storage buffer-Preservative: 0.1% Sodium azideConstituents: 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCD19 is a transmembrane protein also known as B4 or B-lymphocyte antigen CD19 with an approximate molecular weight of 95 kDa. It is expressed on the surface of B cells throughout their development from pro-B cells to mature B cells. CD19 functions mechanically as a coreceptor enhancing the sensitivity of B cell receptor (BCR) signaling. This protein plays a significant role in promoting the activation and proliferation of B cells by lowering the threshold for antigen receptor engagement.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCD19 acts as an essential player in B cell signaling. CD19 integrates signals from the BCR with other coreceptors acting as a signaling hub. It participates in forming a signaling complex that includes proteins like CD21 and CD81 which further amplifies BCR-mediated signaling. This complex plays a critical role in B cell activation differentiation and survival ensuring that immune responses are efficiently mounted against pathogens.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe CD19 protein fits into key immune response pathways such as the BCR signaling pathway and the PI3K-Akt signaling pathway. CD19 collaborates with other proteins like CD21 CD81 and PI3K within these pathways. Its interaction in the PI3K-Akt pathway for instance supports critical processes including B cell activation and homeostasis contributing to the adaptive immune response.\u003cbr\u003e\nCD19 is connected to B cell malignancies and autoimmune diseases. B cell acute lymphoblastic leukemia (ALL) often shows aberrant CD19 expression making it a valuable target for therapeutic interventions like anti-CD19 monoclonal antibodies. Additionally overexpression or mutations of CD19 may contribute to autoimmune diseases by disrupting normal B cell regulation. CD19's connection with proteins like CD22 and CD20 in these pathological contexts highlights its relevance in developing targeted therapies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855347404969,"sku":"ab1168","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab1168","provider":"Iright","version":"1.0","type":"link"}