{"product_id":"abcam-ab116967","title":"Abcam, ab116967, Recombinant Human NEU2 protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human NEU2 protein is a Human Fragment protein, in the 180 to 268 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:ELISA, WB, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q9Y3R4,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.3% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe NEU2 gene encodes for the enzyme neuraminidase 2 also known as sialidase 2. Neuraminidase 2 has a mass of approximately 42 kDa. It plays a critical role in cleaving sialic acids from glycoproteins and glycolipids. NEU2 expression is mainly found in skeletal muscle and has been noted in other tissues such as the heart and kidney. These enzyme activities are important in cell-cell communication and modulation of immune responses.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNeuraminidase 2 participates in the catabolism of sialoglycoconjugates. It is not a part of a larger protein complex but acts independently to remove sialic acids which can alter the properties and functions of substrates like glycoproteins on cell surfaces. These activities impact a number of biological processes including cellular signaling pathways which can influence immune and inflammatory responses.\u003cbr\u003e\nPathways\u003cbr\u003e\nNeuraminidase 2 is involved in the catabolic process of the sialyl group as part of the glycosphingolipid metabolism. It is closely linked to the lysosomal pathway impacting the degradation and recycling of biomolecules. NEU2’s enzymatic work closely relates to other neuraminidases such as NEU1 and neurominidase-3 which have overlapping functions but different tissue distributions and substrate specificities.\u003cbr\u003e\nDeficiencies or dysfunctions in neuraminidase 2 have associations with conditions like sialidosis and galactosialidosis. These disorders arise from improper degradation of sialic acids and can impact multiple systems in the body including the central nervous system. The protein NEU1 is another neuraminidase involved in similar disorders but it primarily contributes to lysosomal storage; together they underline the importance of proper sialic acid metabolism in health.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843894399145,"sku":"ab116967","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab116967","provider":"Iright","version":"1.0","type":"link"}