{"product_id":"abcam-ab120017","title":"Abcam, ab120017, CNQX, AMPA \/ kainate antagonist","description":"\u003cp\u003eSize: 10mg \/ 25mg \/ 50mg\u003cbr\u003e\nMW 232.15 Da, Purity \u0026gt;99%. Potent, competitive AMPA \/ kainate receptor antagonist. Also antagonist at NMDA receptor glycine site.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:115066-14-3,\u003cbr\u003e\nPurity:\u0026gt;99%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:232.15 Da,\u003cbr\u003e\nMolecular formula:C9H4N4O4,\u003cbr\u003e\nPubChem:3721046,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 100 mM,\u003cbr\u003e\nBiochemical name:6-Cyano-7-nitroquinoxaline-2,3-dione,\u003cbr\u003e\nBiological description:Potent, competitive AMPA \/ kainate receptor antagonist. Also antagonist at NMDA receptor glycine site.,\u003cbr\u003e\nCanonical smiles:C1=C(C(=CC2=C1NC(=O)C(=O)N2)[N+](=O)[O-])C#N,\u003cbr\u003e\nInChi:InChI=1S\/C9H4N4O4\/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5\/h1-2H,(H,11,14)(H,12,15),\u003cbr\u003e\nInChiKey:RPXVIAFEQBNEAX-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:7-nitro-2,3-dioxo-1,4-dihydroquinoxaline-6-carbonitrile\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGlutamate Receptor 1 (AMPA subtype) also known as GluA1 or GRIA1 is an ionotropic glutamate receptor that functions as a ligand-gated ion channel. It is part of the AMPA receptor complex. The AMPA receptor modulates synaptic transmission and plasticity by allowing the flow of Na+ and K+ ions upon binding of the neurotransmitter glutamate. These receptors are widely expressed throughout the central nervous system with significant expression in the hippocampus and cerebral cortex regions important for memory and learning. The approximate molecular weight of GluA1 is 99.3 kDa.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGlutamate Receptor 1 plays a pivotal role in excitatory synaptic transmission. It forms tetrameric complexes often including other AMPA receptor subunits like GluA2 GluA3 and GluA4. The assembly of these subunits influences the ion permeability and kinetic properties of the receptor further impacting synaptic strength and plasticity. The receptor's function is important for long-term potentiation (LTP) a cellular mechanism for learning and memory in the brain.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe function of Glutamate Receptor 1 is integral to the glutamatergic signaling pathway an essential pathway for excitatory neurotransmission. It interacts with few other proteins like NMDA receptors which also play an important role in synaptic plasticity and are involved in several synaptic signaling cascades. This receptor is also part of the MAPK signaling pathway which is important in synaptic development and neuronal survival. The crosstalk between AMPA receptors and NMDA receptors allows fine-tuning of synaptic responses and plasticity.\u003cbr\u003e\nGlutamate Receptor 1 is implicated in neurological conditions such as Alzheimer's disease and epilepsy. Altered expression or dysfunction of this receptor can lead to synaptic failure and neurodegeneration commonly observed in Alzheimer's disease. In epilepsy aberrant regulation of AMPA receptor-mediated signaling contributes to excessive excitatory neurotransmission and seizures. The receptor's interaction with NMDA receptors is a focus for therapeutic interventions aiming to regulate excessive activity in these disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847396872361,"sku":"ab120017","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab120017","provider":"Iright","version":"1.0","type":"link"}