{"product_id":"abcam-ab120029","title":"Abcam, ab120029, (R,S)-Rolipram, Selective PDE4 inhibitor","description":"\u003cp\u003eSize: 10mg \/ 50mg\u003cbr\u003e\nMW 275.34 Da, Purity \u0026gt;99%. Selective cAMP-specific phosphodiesterase PDE4 inhibitor (IC 50  values are 1.1 and 0.17 μM for inhibition of mouse PDE4A1 and PDE4B, respectively).\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:61413-54-5,\u003cbr\u003e\nPurity:\u0026gt;99%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:275.34 Da,\u003cbr\u003e\nMolecular formula:C16H21NO3,\u003cbr\u003e\nPubChem:5092,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 100 mMSoluble in ethanol to 100 mM,\u003cbr\u003e\nBiochemical name:Rolipram,\u003cbr\u003e\nBiological description:Selective cAMP-specific phosphodiesterase PDE4 inhibitor (IC50 values are 1.1 and 0.17 μM for inhibition of mouse PDE4A1 and PDE4B, respectively),\u003cbr\u003e\nCanonical smiles:COC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3,\u003cbr\u003e\nInChi:InChI=1S\/C16H21NO3\/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13\/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18),\u003cbr\u003e\nInChiKey:HJORMJIFDVBMOB-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPDE4A or phosphodiesterase 4A is an isoform part of the PDE4 family known for hydrolyzing cAMP an important second messenger in cells. The mass of PDE4A can vary depending on the isoform with commonly referenced masses around 70-100 kDa. This enzyme is expressed in various tissues including the brain immune cells and lungs. Other popular names for this protein include PDE46 and DPDE2 indicating its different isoforms and specific functionalities across tissue types.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPDE4A plays an important role in regulating intracellular levels of cyclic adenosine monophosphate (cAMP) a critical component in signaling pathways that affect numerous cellular processes. By controlling cAMP concentrations PDE4A regulates inflammatory responses and airway smooth muscle contraction which is important for respiratory functions. PDE4A does not function within a complex but operates as a homodimer when exerting its effects on signaling cascades.\u003cbr\u003e\nPathways\u003cbr\u003e\nPDE4A's role is significant in the cAMP-dependent signaling pathway. This pathway influences processes like inflammation and smooth muscle relaxation. PDE4A interacts with various proteins such as PKA (protein kinase A) which is activated by cAMP and mediates several downstream effects. By influencing the cAMP pathway PDE4A affects bodily responses including immune and respiratory systems.\u003cbr\u003e\nPDE4A has implications in conditions such as asthma and chronic obstructive pulmonary disease (COPD). Dysregulation of cAMP through PDE4A can contribute to these respiratory conditions by affecting airway inflammation and muscle tone. PDE4A is also linked to other related proteins such as PDE4B which can also impact inflammatory pathways in similar disease contexts. PDE4 inhibitors have been explored as therapeutic agents for modifying these diseases by targeting the enzymatic activity of PDE4A and related isoforms to restore balanced cAMP levels.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847403425961,"sku":"ab120029","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab120029","provider":"Iright","version":"1.0","type":"link"}