{"product_id":"abcam-ab120117","title":"Abcam, ab120117, QX-314 bromide (N-Ethyllidocaine bromide), Na+ channel blocker","description":"\u003cp\u003eSize: 50mg \/ 100mg \/ 250mg\u003cbr\u003e\nMW 343.3 Da, Purity \u0026gt;99%. A membrane impermeable quaternary lidocaine derivative. Blocks voltage-sensitive Na+ conductance when applied intracellularly. Soluble in 1 ml water to give specified mM\/ml concentration.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:21306-56-9,\u003cbr\u003e\nPurity:\u0026gt;99%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:343.3 Da,\u003cbr\u003e\nMolecular formula:C16H27BrN2O,\u003cbr\u003e\nPubChem:9884487,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nBiochemical name:Lidocaine N-ethyl bromide,\u003cbr\u003e\nBiological description:A membrane impermeable quaternary lidocaine derivative. Blocks voltage-sensitive Na+ conductance when applied intracellularly. Soluble in 1 ml water to give specified mM\/ml concentration.,\u003cbr\u003e\nCanonical smiles:CC[N+](CC)(CC)CC(=O)NC1=C(C=CC=C1C)C.[Br-],\u003cbr\u003e\nInChi:InChI=1S\/C16H26N2O.BrH\/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;\/h9-11H,6-8,12H2,1-5H3;1H,\u003cbr\u003e\nInChiKey:DLHMKHREUTXMCH-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:[2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium;bromide\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMuscarinic acetylcholine receptors M4 (CHRM4) and M5 (CHRM5) are types of G protein-coupled receptors (GPCRs) that interact with the neurotransmitter acetylcholine. CHRM4 has a molecular mass around 49 kDa while CHRM5's mass is approximately 53 kDa. CHRM4 is expressed in areas like the cortex hippocampus and striatum while CHRM5 is found in regions like the basal forebrain and the thalamus. These receptors mediate different physiological responses through the modulation of intracellular signaling pathways.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMuscarinic acetylcholine receptors are critical in regulating functions such as cognitive processing motor control and autonomic nervous system actions. They do not operate as part of a multi-protein complex but engage in signaling mechanisms after neurotransmitter binding. Both receptor types contribute to neural circuitry by activating phosphoinositide breakdown and modulating cyclic AMP levels.\u003cbr\u003e\nPathways\u003cbr\u003e\nMuscarinic acetylcholine receptors participate in the cholinergic signaling pathway. This pathway is essential for neurotransmission in the central and peripheral nervous systems. Interaction with G proteins particularly Gi\/o for CHRM4 and Gq\/11 for CHRM5 allows these receptors to influence downstream effectors like phospholipase C. Other proteins related to this pathway include the nicotinic acetylcholine receptors that also bind acetylcholine to propagate neural signals.\u003cbr\u003e\nMuscarinic acetylcholine receptors are linked to conditions like schizophrenia and Alzheimer's disease. CHRM4 appears connected to schizophrenia likely due to its role in modulating dopaminergic and glutamatergic neurotransmission. CHRM5 through its signaling pathways relates to Alzheimer’s impacting cognitive functions. Both receptors maintain interactions with proteins like the NMDA receptor in the context of these disorders influencing their pathophysiological roles.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847406735529,"sku":"ab120117","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab120117","provider":"Iright","version":"1.0","type":"link"}