{"product_id":"abcam-ab120236","title":"Abcam, ab120236, Rasagiline mesylate, MAO-B inhibitor","description":"\u003cp\u003eSize: 10mg \/ 50mg\u003cbr\u003e\nMW 267.35 Da, Purity \u0026gt;99%. Selective, irreversible monoamine oxidase B (MAO-B) inhibitor, with anti-Parkinson activity. In cell culture (PC-12 and neuroblastoma SH-SY5Y cells) it exhibits neuroprotective and anti-apoptotic activity against several neurotoxins.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:161735-79-1,\u003cbr\u003e\nPurity:\u0026gt;99%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:267.35 Da,\u003cbr\u003e\nMolecular formula:C13H17NO3S,\u003cbr\u003e\nPubChem:3052775,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nBiochemical name:Rasagiline mesylate,\u003cbr\u003e\nBiological description:Selective, irreversible monoamine oxidase B (MAO-B) inhibitor, with anti-Parkinson activity. In cell culture (PC-12 and neuroblastoma SH-SY5Y cells) it exhibits neuroprotective and anti-apoptotic activity against several neurotoxins.,\u003cbr\u003e\nCanonical smiles:CS(=O)(=O)O.C#CCNC1CCC2=CC=CC=C12,\u003cbr\u003e\nIsomeric smiles:CS(=O)(=O)O.C#CCN[C@@H]1CCC2=CC=CC=C12,\u003cbr\u003e\nInChi:InChI=1S\/C12H13N.CH4O3S\/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12;1-5(2,3)4\/h1,3-6,12-13H,7-9H2;1H3,(H,2,3,4)\/t12-;\/m1.\/s1,\u003cbr\u003e\nInChiKey:JDBJJCWRXSVHOQ-UTONKHPSSA-N,\u003cbr\u003e\nIUPAC Name:methanesulfonic acid;(1R)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMonoamine oxidase A and B (MAO-A and MAO-B) are enzymes that reside primarily in the outer membrane of mitochondria. They catalyze the oxidative deamination of monoamines which include neurotransmitters such as serotonin dopamine and norepinephrine. MAO-A has a molecular mass of approximately 59 kDa while MAO-B is around 58 kDa. These enzymes are expressed in various tissues with high levels in the brain liver and gastrointestinal tract. They are also known as MAO-A and MAO-B and they play a critical role in regulation of synaptic neurotransmitter levels.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThese enzymes are important for modulating the activity and concentration of neurotransmitters within the central nervous system and peripheral tissues. MAO enzymes ensure proper neurotransmitter homeostasis which affects mood arousal and stress response. They do not form part of larger enzyme complexes but regulate neurotransmitter concentrations individually. The functional balance between MAO-A and MAO-B activity is important for maintaining normal physiological and psychological states.\u003cbr\u003e\nPathways\u003cbr\u003e\nThese enzymes are integral to the catecholamine and serotonin degradation pathways. MAO-A preferentially degrades serotonin and norepinephrine whereas MAO-B primarily acts on phenylethylamine and benzylamine although both can oxidize dopamine. Related proteins within these pathways include catechol-O-methyltransferase (COMT) and aldehyde dehydrogenases which continue the breakdown processes of monoamines into their final excretory products.\u003cbr\u003e\nDysfunction of MAO-A and MAO-B has links to psychiatric and neurodegenerative disorders. MAO-A abnormalities are associated with depression and mood disorders while altered MAO-B activity correlates with Parkinson’s disease. The imbalance involving these enzymes can affect neurotransmitter levels leading to disease progression. Proteins such as alpha-synuclein associated with Parkinson's disease have connections to MAO-B through their functional roles in dopaminergic neuron degeneration.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847446548649,"sku":"ab120236","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab120236","provider":"Iright","version":"1.0","type":"link"}