{"product_id":"abcam-ab120383","title":"Abcam, ab120383, UDP sodium salt (Uridine 5'-diphosphate), P2Y6 agonist. P2Y14 ligand.","description":"\u003cp\u003eSize: 100mg \/ 500mg\u003cbr\u003e\nMW 470.11 Da, Purity \u0026gt;98%. Endogenous P2Y receptor agonist which preferentially activates P2Y6. Antagonist and agonist activities reported at human P2Y14 receptors. Potent full agonist at rat P2Y12 (EC50 = 350 nM).\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:19817-91-5,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:470.11 Da,\u003cbr\u003e\nMolecular formula:C9H11N2Na3O12P2,\u003cbr\u003e\nPubChem:88264,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in water to 100 mM,\u003cbr\u003e\nBiochemical name:Uridine 5'-(trisodium pyrophosphate),\u003cbr\u003e\nBiological description:Endogenous P2Y receptor agonist which preferentially activates P2Y6. Antagonist and agonist activities reported at human P2Y14 receptors. Potent full agonist at rat P2Y12 (EC50 = 350 nM).,\u003cbr\u003e\nCanonical smiles:C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)([O-])OP(=O)([O-])[O-])O)O.[Na+].[Na+].[Na+],\u003cbr\u003e\nIsomeric smiles:C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)([O-])OP(=O)([O-])[O-])O)O.[Na+].[Na+].[Na+],\u003cbr\u003e\nInChi:InChI=1S\/C9H14N2O12P2.3Na\/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18;;;\/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18);;;\/q;3*+1\/p-3\/t4-,6-,7-,8-;;;\/m1...\/s1,\u003cbr\u003e\nInChiKey:GFASEGWJDXDCKZ-LLWADOMFSA-K,\u003cbr\u003e\nIUPAC Name:trisodium;[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] phosphate\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGPR17 also known as G protein-coupled receptor 17 is a member of the G protein-coupled receptor (GPCR) family. This receptor has a molecular weight of approximately 40 kDa. It is expressed in various tissues with significant levels found in the central nervous system including the brain and spinal cord. GPR17 also shows expression in kidneys liver and heart. It is classified under the class A Rhodopsin-like family and is an orphan receptor meaning its natural ligand is not completely established but is thought to be associated with uridine nucleotides and cysteinyl leukotrienes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGPR17 is involved in several physiological processes particularly in the regulation of inflammation and myelination within the central nervous system. It plays a critical role in the differentiation of oligodendrocyte precursor cells into mature oligodendrocytes which are essential for myelin sheath formation and repair of neural damage. GPR17 is not known to function as part of a larger receptor complex but it interacts with intracellular signaling pathways to modulate these cellular processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nGPR17 integrates into inflammatory response pathways and neural cell development pathways. It is actively involved in the nucleotide signaling pathway which is important for responses to tissue damage and initiating repair processes. GPR17 shares functional connections with proteins such as P2Y receptors which also respond to nucleotides and are involved in diverse cellular responses including muscle contraction and platelet aggregation.\u003cbr\u003e\nGPR17's expression and role connect it to multiple sclerosis and brain ischemia. In multiple sclerosis dysregulation of GPR17 can affect the formation and maintenance of the myelin sheath contributing to neural degeneration. During brain ischemia GPR17 activation influences the extent of injury and subsequent recovery through its effects on inflammation and tissue repair. It is linked to proteins like CXCR7 which similarly influence neural damage and repair processes in ischemic conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847424331945,"sku":"ab120383","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab120383","provider":"Iright","version":"1.0","type":"link"}