{"product_id":"abcam-ab120582","title":"Abcam, ab120582, 8-Hydroxy-DPAT hydrobromide, 5-HT1a receptor agonist","description":"\u003cp\u003eSize: 10mg \/ 50mg\u003cbr\u003e\nMW 328.29 Da, Purity \u0026gt;95%. Standard selective 5-HT1a receptor agonist. Moderate affinity for 5-HT7 receptors (pKi = 6.6) and able to antagonise 5-HT reuptake. Variety of biological effects seen *in vivo*.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:76135-31-4,\u003cbr\u003e\nPurity:\u0026gt;95%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:328.29 Da,\u003cbr\u003e\nMolecular formula:C16H26BrNO,\u003cbr\u003e\nPubChem:6917794,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in water to 10 mMSoluble in ethanol to 5 mM,\u003cbr\u003e\nBiochemical name:8-Hydroxy-2-dipropylaminotetralin hydrobromide,\u003cbr\u003e\nBiological description:Standard selective 5-HT1a receptor agonist. Moderate affinity for 5-HT7 receptors (pKi = 6.6) and able to antagonise 5-HT reuptake. Variety of biological effects seen *in vivo*.,\u003cbr\u003e\nCanonical smiles:CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O.Br,\u003cbr\u003e\nInChi:InChI=1S\/C16H25NO.BrH\/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14;\/h5-7,14,18H,3-4,8-12H2,1-2H3;1H,\u003cbr\u003e\nInChiKey:BATPBOZTBNNDLN-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol;hydrobromide\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe 5HT2A receptor also known as 5-hydroxytryptamine receptor 2A is a G-protein coupled receptor with a molecular mass of approximately 52 kDa. It is one of the key receptors for serotonin (5-HT) and is chiefly expressed in the central nervous system including regions like the cortex and the basal ganglia. This receptor binds serotonin and initiates a cascade of intracellular events which can alter neuronal activity and influence various neuropsychological functions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe 5HT2A receptor modulates cognitive functions such as learning and memory and it also plays a role in mood regulation. This receptor is involved in a complex of signaling pathways and interacts with other receptors such as the 5HT1A receptor and proteins like phospholipase C in downstream signaling. Through these interactions the receptor contributes to maintaining a balance in neurotransmitter systems.\u003cbr\u003e\nPathways\u003cbr\u003e\nThis receptor is actively involved in the serotonergic signaling pathway. It participates by interacting with the phosphatidylinositol signaling system affecting intracellular calcium levels. The 5HT2A receptor works alongside other proteins such as the dopamine D2 receptor forming a link between serotonin and dopamine pathways which are integral to mood and behavior regulation.\u003cbr\u003e\nThe 5HT2A receptor is closely linked to schizophrenia and depression. Alterations in the receptor's function or expression levels have been associated with the pathophysiology of these disorders. The receptor's interactions with other proteins including the 5HT1A receptor have been implicated in the therapeutic mechanisms of antipsychotic and antidepressant medications highlighting its significance in mental health treatment strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847475646633,"sku":"ab120582","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab120582","provider":"Iright","version":"1.0","type":"link"}