{"product_id":"abcam-ab120617","title":"Abcam, ab120617, PP3, Negative control for PP2","description":"\u003cp\u003eSize: 10mg \/ 50mg \/ 100mg\u003cbr\u003e\nMW 211.22 Da, Purity \u0026gt;97%. Negative control for the Src kinase inhibitor PP2 (ab120308). Inhibits EGFR kinase (IC 50  = 2.7 μM).\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:5334-30-5,\u003cbr\u003e\nPurity:\u0026gt;97%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:211.22 Da,\u003cbr\u003e\nMolecular formula:C11H9N5,\u003cbr\u003e\nPubChem:4879,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in ethanol to 25 mMSoluble in DMSO to 100 mM,\u003cbr\u003e\nBiochemical name:1-Phenyl-1h-pyrazolo[3,4-d]pyrimidin-4-amine,\u003cbr\u003e\nBiological description:Negative control for the Src kinase inhibitor PP2 (ab120308). Inhibits EGFR kinase (IC50 = 2.7 μM).,\u003cbr\u003e\nCanonical smiles:C1=CC=C(C=C1)N2C3=NC=NC(=C3C=N2)N,\u003cbr\u003e\nInChi:InChI=1S\/C11H9N5\/c12-10-9-6-15-16(11(9)14-7-13-10)8-4-2-1-3-5-8\/h1-7H,(H2,12,13,14),\u003cbr\u003e\nInChiKey:KKDPIZPUTYIBFX-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:1-phenylpyrazolo[3,4-d]pyrimidin-4-amine\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nEGFR also known as epidermal growth factor receptor is a membrane-bound protein with a mass of approximately 170 kDa. It is expressed in many cell types including epithelial tissues. EGFR has tyrosine kinase activity and plays an important role in the regulation of cell growth and differentiation. PI4K2B PI4 kinase beta also known as PI4KB shares a similar functional landscape. With a mass of about 92 kDa PI4KB localizes mainly in the cytoplasm and trans-Golgi network and participates in phosphatidylinositol (PI) phosphorylation converting PI to phosphatidylinositol 4-phosphate (PI4P). PI4K2A has a function similar to PI4KB in lipid-mediated signaling.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nEGFR participates in signal transduction cascades that promote cellular proliferation and survival. It often forms homodimers or heterodimers with other receptors in the cell membrane upon ligand binding. PI4K2B acting within lipid microdomains regulates membrane trafficking and assignation of signaling proteins to various cell functions. It does not necessarily work alone and could be a component of larger protein complexes that control phosphorylation dynamics. Both PI4KB and PI4K2A have recognized roles in the maintenance of PI4P levels within cells affecting vesicular trafficking.\u003cbr\u003e\nPathways\u003cbr\u003e\nEGFR primarily associates with the MAPK and PI3K-Akt signaling pathways influencing cell cycle progression and apoptosis. Key interactions with proteins such as Src enhance downstream signaling and functional outcomes. PI4K2B and PI4KB integrate into pathways that involve phosphatidylinositol metabolism playing roles alongside proteins such as PIP kinase and serving as important nodes in PI3P-related pathways. These connections influence cellular trafficking and organelle function.\u003cbr\u003e\nEGFR overexpression or mutations relate to cancers notably lung cancer and glioblastoma through altered signaling pathways resulting in unchecked cell division. Its interaction with Src renders it a target for inhibitors like PP2 Src inhibitors in therapeutic investigations. PI4KB dysregulation associates with neurological diseases where disruptions in PI4P balance affect neurodegenerative disease progression. Therefore EGFR and PI4K enzymes are linked to cancer and neurological disorders where their pathways intertwine with disease-specific alterations in protein networks.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847417548969,"sku":"ab120617","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab120617","provider":"Iright","version":"1.0","type":"link"}