{"product_id":"abcam-ab121973","title":"Abcam, ab121973, Anti-MYOM3 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal MYOM3 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MYOM3 aa 300-450.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human MYOM3 aa 300-450. The exact immunogen used to generate this antibody is proprietary information.Q5VTT5\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe MYOM3 protein also known as Myomesin 3 is an integral component of muscle architecture. It plays a mechanical role within sarcomeres where it connects thick and thin filaments to facilitate contraction. The protein has a mass of approximately 193 kDa and is predominantly expressed in cardiac and skeletal muscle tissues. MYOM3 is part of the MyBP-C complex which interacts to maintain muscle structure and flexibility under mechanical stress.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe MYOM3 protein functions to stabilize muscle fibers during contraction. It contributes to the structural integrity of the M-line within their sarcomeric arrangement. MYOM3 operates alongside other proteins in muscular tissues including MYOM1 and MYOM2 forming strong elastic connections. This protein complex contributes to muscle elasticity and contraction important for regular muscle function.\u003cbr\u003e\nPathways\u003cbr\u003e\nMYOM3 integrates into muscle-specific signaling networks. It plays a role in the sarcomeric assembly pathways important for muscle fiber formation and maintenance. MYOM3 interacts with titin and nebulin—both significant in sarcomeric structure organization—helping maintain the functional integrity of muscle fibers under stress. This protein's interactions highlight its contribution to the mechanisms that govern muscle contraction and relaxation cycles.\u003cbr\u003e\nMutations or malfunctions in the MYOM3 protein can contribute to myopathies such as hypertrophic cardiomyopathy and certain congenital myopathies. These conditions often implicate other sarcomeric proteins like titin or MYH7 which closely interact with MYOM3. Understanding MYOM3's role in these disorders assists in elucidating disease progression and finding potential therapeutic interventions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854223298729,"sku":"ab121973","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab121973","provider":"Iright","version":"1.0","type":"link"}