{"product_id":"abcam-ab122177","title":"Abcam, ab122177, Anti-Nance-Horan Syndrome Protein antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal Nance-Horan Syndrome Protein antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human NHS aa 1100-1300.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human NHS aa 1100-1300. The exact immunogen used to generate this antibody is proprietary information.Q6T4R5\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNance-Horan Syndrome Protein also known as NHS plays an important role within the cell. Mechanically NHS is involved in cytoskeleton organization and cell morphogenesis. The protein has a mass of approximately 163 kDa. It is expressed in a range of tissues with notable expression in the eye and craniofacial regions. The NHS protein is important for proper cellular structure and organization of the actin cytoskeleton.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe Nance-Horan Syndrome Protein is involved in cell differentiation and development. It acts as part of a larger protein complex that regulates cellular stability and morphology. This involvement is essential in maintaining the integrity of tissues particularly in areas like the eye lens and dental structures where precise cell architecture is significant for function. The protein's specific interactions in these biological processes highlight its importance within dynamic cellular environments.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe Nance-Horan Syndrome Protein intersects with developmental signaling pathways. It particularly associates with the Wnt signaling pathway which is critical for tissue morphogenesis and cell fate determination. In this pathway NHS interacts with proteins such as β-catenin helping regulate gene expression and maintaining tissue-specific functions. The NHS protein's activity within this pathway supports the development of anatomical structures necessitating precise cellular communication.\u003cbr\u003e\nThe Nance-Horan Syndrome Protein is closely linked to Nance-Horan Syndrome an X-linked developmental disorder. This syndrome primarily affects the eyes teeth and face demonstrating how disruptions in NHS function can lead to pronounced phenotype alterations. Additionally mutations or malfunctions in NHS can relate to congenital cataracts further emphasizing its role in ocular development. Proteins like FOXC1 have connections with NHS-related pathways illustrating its broader implications in embryonic development and disease manifestation.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848631144617,"sku":"ab122177","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab122177","provider":"Iright","version":"1.0","type":"link"}