{"product_id":"abcam-ab122374","title":"Abcam, ab122374, Anti-PRMT10 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal PRMT10 antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PRMT9 aa 200-350.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human PRMT9 aa 200-350. The exact immunogen used to generate this antibody is proprietary information.Q6P2P2\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPRMT10 also known as Protein Arginine Methyltransferase 10 participates in the methylation of arginine residues in target proteins. This enzyme functions mainly in cellular locations such as the nucleus and the cytoplasm. Weighing around 64 kDa PRMT10 modifies histones through methylation playing a critical role in transcriptional regulation and other chromatin-related processes. Expression of PRMT10 can be seen across many tissues with higher levels found in actively dividing cells due to its role in cell cycle regulation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPRMT10 affects chromatin structure and gene expression by methylating histones and other substrates. This protein often associates with complexes involved in transcriptional repression or activation. It targets histones like H3 and H4 influencing the recruitment of transcriptional machinery and chromatin remodelers. Through its enzymatic activity PRMT10 impacts processes like gene silencing DNA repair and signal transduction.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe enzymatic activity of PRMT10 integrates with several cellular pathways. It prominently operates in the regulation of the Wnt signaling pathway and the cell cycle control pathway. PRMT10 works alongside related proteins such as β-catenin in Wnt signaling modulating gene expression patterns critical for cell growth and differentiation. Furthermore its interaction with cyclin-dependent kinases (CDKs) highlights its involvement in cell cycle checkpoints.\u003cbr\u003e\nPRMT10 has been linked to cancer and neurodegenerative diseases. Aberrant expression and function of PRMT10 contribute to tumorigenesis by influencing oncogene and tumor suppressor gene expression. In cancer PRMT10 interacts with proteins like Myc enhancing its transcriptional activity which promotes cell proliferation. In neurodegenerative disorders altered PRMT10 activity affects neuronal gene expression highlighting its potential as a therapeutic target.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854215073961,"sku":"ab122374","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab122374","provider":"Iright","version":"1.0","type":"link"}