{"product_id":"abcam-ab125569","title":"Abcam, ab125569, Recombinant Human GRB7 protein","description":"\u003cp\u003eSize: 20µg\u003cbr\u003e\nRecombinant Human GRB7 protein is a Human Full Length protein, in the 1 to 532 aa range, expressed in Escherichia coli, with \u0026gt;90%, suitable for SDS-PAGE, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;90% Densitometry,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:Tag free,\u003cbr\u003e\nApplications:WB, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q14451,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 7.5Constituents: 25% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.79% Tris HCl, 0.31% Glutathione, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGRB7 also known as Growth Factor Receptor-Bound Protein 7 is a signaling adapter protein with a molecular mass of approximately 55 kDa. It facilitates interactions between receptor tyrosine kinases and downstream signaling molecules. GRB7 is found in several tissues notably in breast and ovarian tissues. The protein plays a significant role in processes like cell migration and growth by mediating signal transduction pathways.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nProteins like GRB7 interact with various cell surface receptors. GRB7 forms part of signaling complexes that modulate diverse cellular responses essential for cell communication and function. As an adapter protein GRB7 binds with SH2 and PH domains to facilitate signal transduction directly influencing cellular proliferation and movement. Its expression links with cell motility indicating its relevance in cellular responses such as migration and adhesion.\u003cbr\u003e\nPathways\u003cbr\u003e\nProteins influencing GRB7 highlight its involvement in several signaling pathways notably the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K) pathways. These pathways play important roles in regulating cellular processes like growth survival and migration. GRB7 interacts closely with other proteins such as HER2 often amplifying the signaling related to growth factors further indicating its critical role in signal transduction networks.\u003cbr\u003e\nGRB7 has implications in cancer and related abnormalities. In particular abnormal GRB7 expression is linked to breast cancer and ovarian cancer often associated with tumor progression and metastasis. It frequently associates with the HER2 protein a known player in aggressive cancer subtypes serving as a potential therapeutic target and prognostic marker. Understanding GRB7's involvement offers insights into new treatment strategies for these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843927429289,"sku":"ab125569","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab125569","provider":"Iright","version":"1.0","type":"link"}