{"product_id":"abcam-ab125864","title":"Abcam, ab125864, Anti-Phosphoribosyl pyrophosphate amidotransferase antibody","description":"\u003cp\u003eSize: 50µL\u003cbr\u003e\nRabbit Polyclonal Phosphoribosyl pyrophosphate amidotransferase antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PPAT aa 250-500.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human PPAT aa 250-500. The exact immunogen used to generate this antibody is proprietary information.Q06203\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPhosphoribosyl pyrophosphate amidotransferase also called PRPP amidotransferase is an enzyme that facilitates the conversion of phosphoribosyl pyrophosphate and glutamine into phosphoribosylamine in de novo purine synthesis. This enzyme has a molecular mass of approximately 59 kDa and is highly expressed in tissues with active nucleotide synthesis such as the liver and proliferating cells. Phosphoribosyl diphosphate amidotransferase serves a vital role in providing the building blocks for DNA and RNA synthesis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPRPP amidotransferase functions as an important regulator in the purine biosynthetic pathway. The enzyme does not function as part of a complex but instead acts independently to initiate the first committed step of purine nucleotide biosynthesis. It effectively sets the pace for the entire biosynthetic process responding to levels of its substrates and product feedback inhibition particularly by purine nucleotides.\u003cbr\u003e\nPathways\u003cbr\u003e\nPurine biosynthesis involves the activity of PRPP amidotransferase which is central to both nucleotide biosynthesis and energy metabolism. This enzyme significantly cross-talks with the aminotransferase pathway to ensure proper cellular levels of nucleotides. It closely interacts with other enzymes such as adenylosuccinate synthetase to manage proper nucleoside and nucleotide production within cells.\u003cbr\u003e\nPRPP amidotransferase imbalance is linked to various conditions such as gout and certain types of cancer. Dysregulation in enzyme activity can lead to increased purine production thereby contributing to hyperuricemia and gout. This enzyme is also connected to proteins like hypoxanthine-guanine phosphoribosyltransferase where imbalances in activity can exacerbate gout conditions or influence cancer cell proliferation. Understanding these connections aids in the development of therapeutic strategies targeting nucleotide synthesis pathways in disease treatment.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854152945833,"sku":"ab125864","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab125864","provider":"Iright","version":"1.0","type":"link"}