{"product_id":"abcam-ab126194","title":"Abcam, ab126194, Anti-SNIP1 antibody","description":"\u003cp\u003eSize: 50µL\u003cbr\u003e\nRabbit Polyclonal SNIP1 antibody. Suitable for IHC-P, WB and reacts with Mouse, Rat, Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SNIP1 aa 1-350.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human SNIP1 aa 1-350. The exact immunogen used to generate this antibody is proprietary information.Q8TAD8\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSNIP1 also known as Smad nuclear interacting protein 1 is a nuclear protein with a mass of approximately 43 kDa. This protein mechanically functions as a nuclear co-repressor that interacts with Smad proteins and the transcription factor c-Myc. SNIP1 is expressed in various tissues notably in embryonic and adult brain tissues which indicates a role in development and cellular regulation within these areas.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSNIP1 influences transcriptional repression by modulating the transcriptional activity of the Smad4 complex. SNIP1 interacts with several regulatory proteins to modulate gene expression. By inhibiting the transcriptional activity of Smad proteins SNIP1 can regulate various genes involved in cell growth and proliferation affecting how cells behave in different contexts.\u003cbr\u003e\nPathways\u003cbr\u003e\nSNIP1 participates in important cellular signaling pathways such as the TGF-beta and BMP signaling pathways. SNIP1 interacts with proteins in these pathways including Smad2 and Smad3 to control cellular responses to growth factors. By influencing these pathways SNIP1 plays a part in cellular processes like apoptosis and differentiation.\u003cbr\u003e\nSNIP1 has implications in cancer and neurodevelopmental disorders. In cancer SNIP1's interaction with proteins like c-Myc and Smad3 plays a role in tumor progression highlighting its involvement in oncogenic pathways. In neurodevelopmental disorders altered SNIP1 expression affects normal brain development suggesting links between its expression and conditions such as autism spectrum disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854362824873,"sku":"ab126194","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab126194","provider":"Iright","version":"1.0","type":"link"}