{"product_id":"abcam-ab126345","title":"Abcam, ab126345, Anti-EXOC3L4 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal EXOC3L4 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human EXOC3L4 aa 50-200.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human EXOC3L4 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.Q17RC7\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nEXOC3L4 also known as exocyst complex component 3-like 4 is a protein with a mass of approximately 38 kDa. It functions as a component of the exocyst complex a multi-protein assembly involved in the docking and fusion of vesicles with the plasma membrane. This protein plays a role in vesicle trafficking contributing to processes that require directed membrane addition or secretion. EXOC3L4 expression is variable with evidence showing occurrence in several tissue types but further research is needed to map its expression profile fully.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe protein supports cellular activities involving vesicular transport. EXOC3L4 acts as a part of the exocyst complex an important player in tethering vesicles at specific sites on the plasma membrane in mammalian cells. This function is important for maintaining normal cell surface homeostasis and supporting processes such as cell migration growth and division. The exocyst complex interfaces with the actin cytoskeleton aiding precise vesicle guidance and targeting.\u003cbr\u003e\nPathways\u003cbr\u003e\nThis protein is integral to the secretory pathway and cellular trafficking mechanisms. EXOC3L4 interacts closely with components of the exocyst pathway including EXOC1 through EXOC8. Within these pathways it helps ensure that exocytosis and endocytosis occur efficiently. It also interacts with proteins like Rho GTPases linking EXOC3L4 to signaling pathways that assist in dictating cellular architecture and dynamics.\u003cbr\u003e\nEXOC3L4 is currently linked to certain cellular dysfunctions although specific pathological conditions remain under investigation. Disruption in its function may relate to cancerous growths given its role in vesicle trafficking which affects cell migration. Mutations or altered expression levels could potentially influence cancer progression. Moreover EXOC3L4's interactions with other exocyst proteins like EXOC2 suggest its possible involvement in conditions where exocytosis is impaired pointing towards neurological disorders as another area of interest for future research.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854166282409,"sku":"ab126345","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab126345","provider":"Iright","version":"1.0","type":"link"}