{"product_id":"abcam-ab126788","title":"Abcam, ab126788, Anti-PTPRE antibody [EPR6715]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal PTPRE antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Mouse, Human samples. Cited in 3 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR6715,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPTPRE also known as Protein Tyrosine Phosphatase Receptor Type E or PTPε acts as a tyrosine phosphatase that removes phosphate groups from specific tyrosine residues on proteins. This enzyme which has a molecular mass of approximately 83 kDa functions as a receptor-type phosphatase with roles in cell signaling. PTPRE is expressed across various tissues including high levels in the brain and testis suggesting diverse functional roles in different cellular contexts.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nProtein Tyrosine Phosphatase Receptor Type E regulates cellular processes such as growth differentiation and motility by modulating the phosphorylation state of key signaling components. PTPRE is not known as part of a specific protein complex but interacts with various proteins through its enzymatic activity. It maintains balance in cellular signal transduction processes by counterbalancing kinases which add phosphate groups. This regulatory role indicates its involvement in many critical cellular activities and responses.\u003cbr\u003e\nPathways\u003cbr\u003e\nProtein Tyrosine Phosphatase Receptor Type E influences the MAPK\/ERK pathway which plays an important role in cell division and the JAK\/STAT signaling pathway important for immune response. In these pathways PTPRE interacts and regulates proteins such as ERK and STAT respectively. By modulating phosphorylation PTPRE influences pathway signaling outcomes and cellular responses to external stimuli showing its integrative role in controlling signal transduction dynamics.\u003cbr\u003e\nProtein Tyrosine Phosphatase Receptor Type E has been associated with cancer and autoimmune diseases. PTPRE's activity in dephosphorylating targets like ERK and STAT can impact cell proliferation and immune regulation linking it to tumor growth and immune dysregulation. In some cancers abnormal PTPRE activity interacts with other signaling proteins such as Src-family kinases influencing oncogenic processes. This association makes PTPRE a protein of interest for understanding and potentially targeting disease mechanisms.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848560201897,"sku":"ab126788","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab126788","provider":"Iright","version":"1.0","type":"link"}