{"product_id":"abcam-ab127912","title":"Abcam, ab127912, Anti-LRRC59 antibody","description":"\u003cp\u003eSize: 50µL\u003cbr\u003e\nRabbit Polyclonal LRRC59 antibody. Suitable for WB, IHC-P, ICC\/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human LRRC59 aa 1-200.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human LRRC59 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.Q96AG4\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab127912 is purified by antigen-affinity chromatography., Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe protein LRRC59 also known as Leucine-Rich Repeat-Containing Protein 59 is involved in several cellular processes. This protein has a molecular mass of approximately 40 kDa and is expressed in various tissues including the liver kidney and brain. LRRC59 contains multiple leucine-rich repeats which are structural motifs contributing to protein-protein interactions. These interactions are important for the protein's function within the cell.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nLRRC59 is involved in nuclear import pathways and acts as an anchor for certain proteins that need to be translocated into the nucleus. It interacts with the importin-family proteins to facilitate the transport of proteins with nuclear localization signals. LRRC59 works as a part of a larger protein complex which includes importin and nucleoporins to control transport into the nucleus. This positioning suggests that LRRC59 has an active role in regulating gene expression by controlling the nuclear entry of transcription factors and other nuclear proteins.\u003cbr\u003e\nPathways\u003cbr\u003e\nLRRC59 plays a part in cellular transport and signaling pathways. It integrates into the nuclear transport pathway directly influencing gene expression by ensuring the proper nuclear import of signaling molecules. In particular it influences the well-known MAPK signaling pathway through interactions with other proteins like importin-β. These associations emphasize LRRC59’s role in maintaining cellular homeostasis and its potential impact on several signaling cascades.\u003cbr\u003e\nLRRC59 has been linked to specific cancers and certain neurodegenerative conditions. Abnormal expression of LRRC59 has been observed in some cancer types suggesting a role in tumor progression possibly through altered nuclear transport. Additionally LRRC59 is associated with Alzheimer's disease due to its interactions with proteins like tau which are involved in the pathological aggregation seen in this disorder. These connections highlight LRRC59 as a potential target for therapeutic interventions in these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854153699497,"sku":"ab127912","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab127912","provider":"Iright","version":"1.0","type":"link"}