{"product_id":"abcam-ab128815","title":"Abcam, ab128815, Anti-PCDH17 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nGoat Polyclonal PCDH17 antibody. Suitable for WB and reacts with Mouse samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human PCDH17 aa 1050-1150.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Goat,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human PCDH17 aa 1050-1150. The exact immunogen used to generate this antibody is proprietary information.O14917\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 99% Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPCDH17 also known as protocadherin-17 is a protein involved in cell-cell adhesion. This protein is a member of the protocadherin family which is part of the cadherin superfamily. It has a molecular weight of approximately 120 kDa. PCDH17 contains cadherin-like domains which facilitate calcium-dependent cell adhesion. The protein is mainly expressed in the brain especially in regions associated with memory and learning such as the hippocampus and the cerebral cortex.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nProtocadherin-17 influences neural circuit formation and maintenance. It acts as a member of trans-synaptic complexes that modulate the connectivity and signaling efficiency between neurons. This protein plays a important role in the reorganization of synaptic connections during neuronal development and in response to environmental stimuli. Studies indicate its contribution to the stabilization of cell-cell interactions necessary for maintaining synaptic specificity.\u003cbr\u003e\nPathways\u003cbr\u003e\nProtocadherin-17 integrates into complex neural pathways involved in synaptic plasticity and neurodevelopment. It interacts with other members of the cadherin family like N-cadherin to modulate synaptic structures and signaling cascades. PCDH17 potentially influences pathways related to calcium signaling which are essential for various neural processes.\u003cbr\u003e\nAlterations in protocadherin-17 expression have been associated with neurological conditions such as epilepsy and schizophrenia. Abnormal expression or mutations in this protein may disrupt synaptic connectivity and function contributing to the pathophysiology of these disorders. Connections between PCDH17 and other cadherins as well as neurotransmitter receptors may influence disease states where aberrant signaling and cell adhesion play roles.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854461456553,"sku":"ab128815","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab128815","provider":"Iright","version":"1.0","type":"link"}