{"product_id":"abcam-ab129495","title":"Abcam, ab129495, Anti-PHF16 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal PHF16 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human JADE3 aa 750 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human JADE3 aa 750 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q92613\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab129495 was affinity purified using an epitope specific to PHF16 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate\/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPHF16 also known as JADE3 is a protein with a mass of approximately 90 kDa. It is a member of the plant homeodomain finger family of proteins. PHF16 contains domains that mediate interactions with other proteins indicating its role in chromatin remodeling and transcription regulation. This protein is widely expressed in tissues including brain liver and lung. Its localization in these tissues suggests its involvement in various cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPHF16 interacts with a range of molecular complexes related to gene expression regulation. It is a component of the HBO1 complex which plays a role in histone acetylation. This complex modifies chromatin structure to facilitate access to DNA for transcription machinery. PHF16 acts by binding to specific histone marks participating in the regulation of transcriptional activation of genes. These functions make it an important player in maintaining proper gene expression levels across diverse cell types.\u003cbr\u003e\nPathways\u003cbr\u003e\nPHF16 influences transcriptional regulation pathways and epigenetic modification pathways. Within these frameworks it closely interacts with other proteins like HBO1 and ING5. PHF16 contributes to the modification of histone acetylation patterns which is important for transcriptional regulation. It assists in setting the epigenetic landscape that determines the transcriptional output of genes involved in cell cycle and development.\u003cbr\u003e\nAltered expression or mutation of PHF16 links to several pathological conditions including cancer and developmental disorders. For example dysregulation of PHF16 expression may contribute to tumorigenesis particularly in breast cancer due to its role in regulating genes essential for cell proliferation. Moreover interactions with proteins like HBO1 and ING5 highlight its importance in pathways disrupted in developmental diseases where epigenetic misregulation plays a significant role. Understanding PHF16's function and interactions provides critical insights into its potential as a therapeutic target in these disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854003196073,"sku":"ab129495","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab129495","provider":"Iright","version":"1.0","type":"link"}