{"product_id":"abcam-ab129965","title":"Abcam, ab129965, Anti-OR51B5 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal OR51B5 antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human OR51B5.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human OR51B5. The exact immunogen used to generate this antibody is proprietary information.Q9H339\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab129965 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen., Storage buffer-pH: 7Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nOR51B5 also known as Olfactory Receptor Family 51 Subfamily B Member 5 is a G-protein-coupled receptor part of the olfactory receptor family. This receptor protein has a molecular mass of approximately 34 kDa and is expressed in the nasal epithelium. OR51B5 detects odorant molecules in the nasal cavity triggering a signal transduction pathway that results in the perception of smell. This detection process is important for the initial step of olfactory signal transmission.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nOlfactory receptors like OR51B5 play significant roles in detecting a wide array of odorants contributing to the sense of smell. Although part of a larger olfactory receptor complex OR51B5 functions alongside other olfactory receptors to facilitate specific odorant recognition and discrimination. Its activity involves interaction with G-proteins which transmit signals to olfactory neurons leading to brain processing and odor identification.\u003cbr\u003e\nPathways\u003cbr\u003e\nOR51B5 participates in the olfactory signaling pathway an important pathway responsible for the sense of smell. It interacts with other G-protein-coupled receptors and shares pathways with proteins such as G-olf which mediates signal transduction following odorant recognition. This interaction plays a significant role in activating adenylate cyclase elevating cAMP levels and eventually opening cyclic nucleotide-gated channels that lead to neuronal depolarization and signal transmission.\u003cbr\u003e\nAlterations or dysfunctions in OR51B5 may associate with anosmia and other olfactory impairments. These conditions involve deficits in the perception of odors often resulting from disruptions in the olfactory receptor functions or pathway signaling. The protein OR51B5 may connect to diseases through interactions with other olfactory receptors and signaling molecules affecting the entire olfactory pathway and sensory perception. Progress in understanding OR51B5's role in such disorders can help in developing therapeutic strategies targeting olfactory dysfunctions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854228574377,"sku":"ab129965","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab129965","provider":"Iright","version":"1.0","type":"link"}